Mechanisms of Mechanotransduction
A Wayne Orr, Brian P Helmke, Brett R Blackman, Martin A Schwartz
Key takeaways
- 01Cells sense and respond to physical forces
- 02This process is called mechanotransduction
- 03Force alters protein shape to create signals
- 04Disruptions in this process can contribute to disease
Physical forces change protein shapes to send signals, a fundamental process for health and disease across all life.
Abstract
Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechano-transducers.
Cite this study
- APA
- A Wayne Orr, Brian P Helmke, Brett R Blackman, & Martin A Schwartz (2006). Mechanisms of Mechanotransduction. https://fasciaresearchdatabase.com/mechanisms-of-mechanotransduction/
- MLA
- A Wayne Orr, et al. "Mechanisms of Mechanotransduction." 2006, https://fasciaresearchdatabase.com/mechanisms-of-mechanotransduction/.
- Chicago
- A Wayne Orr et al. 2006. "Mechanisms of Mechanotransduction.". https://fasciaresearchdatabase.com/mechanisms-of-mechanotransduction/