Mechanisms of Mechanotransduction
A Wayne Orr, Brian P Helmke, Brett R Blackman, Martin A Schwartz
Physical forces change protein shapes to send signals, a fundamental process for health and disease across all life.
Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechano-transducers.
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