Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A++2013
Mathematical Analysis of the Flow of Hyaluronic Acid Around Fascia During Manual Therapy Motions
Max Roman, Hans Chaudhry, Bruce Bukiet, Antonio Stecco,Thomas FindleyThis study used a mathematical model to simulate how different manual therapy techniques affect the flow of hyaluronic acid (HA) within fascia. The researchers compared constant sliding, perpendicular vibration, and tan…
hyaluronanfasciaManual Therapyfluid flowvibration - B2012
Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes
Giuseppe M Campo, Angela Avenoso, Angela D’Ascola, Vera Prestipino, Michele Scuruchi, Giancarlo Nastasi, Alberto Calatr…This study on mouse cartilage cells investigated how different sizes of hyaluronan (HA) affect inflammation. Researchers found that small HA fragments increased the production of several inflammatory markers. In contras…
hyaluronancytokinesNF-kBtoll-like receptor-4chondrocytes - B2012
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism
Jun Li, Daniel J Gorski, Wendy Anemaet, Jennifer Velasco, Jun Takeuchi, John D Sandy, Anna PlaasIn this mouse study, researchers investigated how hyaluronan (HA) injections might protect joints in osteoarthritis. They found that even though the injected HA was cleared from the knee joint in under two hours, a sing…
hyaluronanCD44fibrosisTGF-beta1osteoarthritis - A2012
A RHAMM Mimetic Peptide Blocks Hyaluronan Signaling and Reduces Inflammation and Fibrogenesis in Excisional Skin Wounds
Cornelia Tolg, Sara R Hamilton, Ewa Zalinska, Lori McCulloch, Ripal Amin, Natalia Akentieva, Francoise Winnik, Rashmin…In this animal study, researchers investigated how to reduce scarring during skin wound healing. They developed a peptide, P15-1, designed to interfere with signals from fragmented hyaluronan, a molecule involved in inf…
hyaluronaninflammationfasciaextracellular matrixfibrosis - B2011
The effect of molecular weight on hyaluronan’s cartilage boundary lubricating ability e alone and in combination with proteoglycan 4
J J Kwiecinski, S G Dorosz, T E Ludwig, S Abubacker, Mary K Cowman, T A SchmidtThis study investigated the lubricating ability of hyaluronan (HA) in articular cartilage, focusing on how its molecular weight affects function. Researchers found that higher molecular weight hyaluronan was more effect…
hyaluronanCartilage boundary lubricationProteoglycan 4 (PRG4) - A2011
Hyaluronan as an Immune Regulator in Human Diseases
Paul W Noble, Jiurong Liang, Dianhua JiangThis 2011 narrative review explores the role of hyaluronan (HA) in the immune system. While intact HA is a normal part of the extracellular matrix, fragments of HA produced during tissue injury can act as signals. These…
hyaluronanfascia - B2011
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44
Yuejuan Li, Dianhua Jiang, Jiurong Liang, Eric B Meltzer, Alice Gray, Riu Miura, Lise Wogensen, Yu Yamaguchi, Paul W No…This study investigated the mechanisms behind severe lung fibrosis, a condition where excessive connective tissue builds up in the lungs. Using a mouse model, researchers found that fibroblasts, a type of connective tis…
hyaluronanCD44fibrosis - A2011
High and Low Molecular Weight Hyaluronic Acid Differentially Regulate Human Fibrocyte Differentiation
A S Maharjan, D Pilling, R H GomerFollowing tissue injury, immune cells called monocytes can differentiate into fibrocytes, a cell type involved in healing and fibrosis. This study investigated how different sizes of hyaluronic acid (HA) affect this pro…
hyaluronanfasciafibrocyte differentiationmonocyte - B2011
Fascia redefined: anatomical features and technical relevance in fascial flap surgery
Carla Stecco, Cesare Tiengo, Antonio Stecco, Andrea Porzionato, Veronica Macchi, Robert Stern, Raffaele De CaroFascia has traditionally been seen as a passive wrapping, but this review redefines it as a dynamic tissue with its own complex blood supply and innervation. The authors detail the specific characteristics of different…
hyaluronanfasciaConnective tissueaponeurosisFlaps - A2011
Hyaluronan: From Extracellular Glue to Pericellular Cue
B P TooleHyaluronan is traditionally seen as a biological 'goo' that lubricates joints and holds connective tissues together. This review describes how hyaluronan also functions as an important signaling molecule, or cue, in the…
hyaluronanfasciasignal transductioncancer