Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2019
Hierarchical Hydrogel Composite Interfaces with Robust Mechanical Properties for Biomedical Applications
Yuting Zhu, Qiang Zhang, Xiaoli Shi, Dong HanThis review summarizes advances in hydrogel composites, materials designed to mimic the body's extracellular matrix (ECM). Cells naturally sense and respond to the mechanical properties and physical structure of the ECM…
tissue engineeringECMHydrogels - A+++2019
An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body
Hongyi Li, Chongqing Yang, Yajun Yin, Fang Wang, Min Chen, Liang Xu, Naili Wang, Di Zhang, Xiaoxia Wang, Yiya Kong, Qin…Researchers investigated a potential fluid transport system within the body's fibrous connective tissues, separate from blood and lymphatic vessels. Using fluorescent tracers in cadavers and MRI in volunteers, they visu…
interstitial fluidinterstitiuminterstitial spacesfascia fluid - A+2019
Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial
Patrick Jendricke, Christoph Centner, Denise Zdzieblik, Albert Gollhofer, Daniel KönigThis randomized controlled trial investigated the effects of combining resistance training with a daily intake of 15 grams of specific collagen peptides in premenopausal women. Over 12 weeks, participants trained three…
body composition; collagen peptides; hand-grip strength; leg press; premenopausal; protein supplementation; resistance training - A2019
The diaphragm muscle manual evaluation scale
Bruno Bordoni, Bruno MorabitoThis technical report describes a new method for manually assessing the diaphragm's function, called the Manual Evaluation Diaphragm (MED) scale. The scale is designed to generate a value for the respiratory muscle's mo…
fasciaMyofascialdiaphragmSurgeryphrenic nerve - A2019
Cellular nanoscale stiffness patterns governed by intracellular forces
Nicola Mandriota, Claudia Friedsam, John A Jones-Molina, Kathleen V Tatem, Donald E Ingber, Ozgur SahinCell stiffness is important in many biological processes, but its precise relationship to the forces acting inside the cell has been unclear. In this study, researchers developed a new high-resolution imaging platform t…
Tensegritymechanotransductioncell - cell interaction - A+++2019
Is It All About the Fascia? A Systematic Review and Meta-analysis of the Prevalence of Extramuscular Connective Tissue Lesions in Muscle Strain Injury
Jan Wilke, Luiz Hespanhol, Martin BehrensThis systematic review and meta-analysis examined how often connective tissue is damaged in athletic muscle strains. Researchers analyzed 16 imaging studies and found that lesions to the fascia and tendons are highly pr…
return to play; muscle injury; collagen; imaging; ultrasound; MRI - A2019
Lipedema: friend and foe
Yanira Sanchez-De la Torre, Rita Wadeea, Victoria Rosas, Karen L HerbstLipedema is a chronic disorder characterized by painful, disproportionate fat accumulation in the limbs of women, and is often misdiagnosed as obesity. In this review, researchers examined both the negative ('foe') and…
gynoid fat; hypermobility; lipedema; lymphedema; women - A2019
Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model
S Azizi, A Farsinejad, R Kheirandish, H FatemiThis animal study investigated a potential treatment for osteoarthritis (OA) in rats. Researchers induced OA in the rats' knees and then treated them with intra-articular injections. One group received a combination of…
Osteoarthritis; SRGF; Monosodium iodoacetate; Vitamin C; Histopathology - 1A+2019
The Awareness of the Fascial System
Bruno Bordoni, Marta SimonelliIn this theoretical article, the authors propose a new way of looking at the fascial system, drawing on concepts from quantum physics. They suggest that fascial cells can sense, remember, and even anticipate mechanical…
fasciafascial systemMyofascialquantum physicsphysiology - A+++2019
Vitamin C administration in the critically ill: a summary of recent meta-analyses
Anitra C CarrThis 2019 publication is a summary of recent meta-analyses on the topic of vitamin C administration for critically ill patients. As the full text has not yet been reviewed, a detailed summary of its findings is not avai…
Vitamin CAscorbic acidsepsis - A++2019
Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
Liping Gan, Vladimir Camarena, Sushmita Mustafi, Gaofeng WangIn this study using cell cultures and animal models, researchers investigated how vitamin C might inhibit the spread of triple-negative breast cancer (TNBC). They found that vitamin C, at concentrations achievable throu…
F-actin; HIF-1α; YAP1; hippo pathway; lamellipodia; metastasis; synaptopodin 2; triple-negative breast cancer; vitamin C. - A2019
Fascial Nomenclature: Update on Related Consensus Process
Robert Schleip, Gil Hedley, Can A YucesoyThe term "fascia" is increasingly used across different health-oriented fields, but often inconsistently, which causes confusion. To address this, the Fascia Research Society established a Fascia Nomenclature Committee.…
fascia; terminology; Delphi technique; nomenclature; connective tissue