Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- B2015
Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation
Sami Albeiroti, Katayoun Ayasoufi, [...], Carol A de la MottePlatelets play a key role in responding to tissue injury. This study explores how they interact with hyaluronan, a major component of the extracellular matrix that is involved in inflammation. Researchers demonstrated t…
hyaluronanextracellular matrixDegradationhyaluronidas-2HYAL2 - A2015
Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
S Albeiroti, A Soroosh, C A de la MotteThis 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…
hyaluronanfasciafibrosis - B2015
Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts
Stephen P Evanko, Susan Potter-Perigo, Loreen J Petty, Gail A Workman, Thomas N WightThis study investigated how hyaluronan (HA), a key component of the extracellular matrix, influences the formation of myofibroblasts—cells involved in tissue scarring and fibrosis. Researchers observed that while HA lev…
hyaluronanMyofibroblastTGF-β14-methyl umbelliferonefibronectin; collagen - A2015
Hyaluronan, inflammation and breast cancer progression
Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthyThis narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…
hyaluronaninflammationCD44fasciaBreast cancer - B2015
Hyaluronan Regulates Bone Morphogenetic Protein-7- dependent Prevention and Reversal of Myofibroblast Phenotype
Adam C Midgley, Lucy Duggal, Robert Jenkins, Vincent Hascall, Robert Steadman, Aled O Phillips, Soma MeranThis study on human lung fibroblasts investigated how a protein called BMP7 might counteract fibrosis. Researchers found that BMP7 can prevent and even reverse the formation of myofibroblasts, which are cells that contr…
hyaluronanMyofibroblastTGF-beta1 - C2015
Hyaluronic acid and wound healing
M G Neuman, R M Nanau, L Oruna-Sanchez, G CotoIn this systematic review, researchers compiled studies on hyaluronic acid (HA) and wound healing published from 2010–2014. The review found that HA is used for tissue regeneration, either alone or in combination with o…
hyaluronanwound healing - A++2015
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
Jaime M Cyphert, Carol S Trempus, Stavros GarantziotisThis narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…
hyaluronanCell signalingmolecular size - A2015
The content and size of hyaluronan in biological fluids and tissues
Mary K Cowman, Hong-Gee Lee, Kathryn L Schwertfeger, James B McCarthy,, Eva A TurleyHyaluronan is a simple sugar polymer found throughout the body's tissues and fluids. It is typically produced as a very large, high-molecular-mass molecule. This narrative review notes that during processes like inflamm…
hyaluronanfasciaquantificationassaymolecular mass