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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 13–19 of 19 studies · page 2/2mechanotransductionSince 2010
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  1. B
    2018

    Cellular Mechanotransduction: From Tension to Function

    F Martino, A R Perestrelo, V Vinarský, S Pagliari, G Forte

    In this review article, the authors describe mechanotransduction—the process by which cells sense and respond to physical forces from their environment, such as the extracellular matrix. These mechanical cues are conver…

    mechanotransductionnucleoskeletonfocal adhesionmechanobiologymechanosensor
  2. A
    2018

    Fascial well-being: Mechanotransduction in manual and movement therapies

    Leon Chaitow

    This article discusses mechanotransduction, the process by which cells in connective tissue sense and respond to mechanical forces like stretch, compression, and shear. Specialized cells such as fibroblasts communicate…

    mechanotransduction
  3. A++
    2017

    Telocytes: Connective tissue repair and communication cells

    Leon Chaitow

    This commentary highlights a newly identified type of connective tissue cell called a telocyte. We already know that other cells, like fibroblasts, respond to mechanical forces from manual therapy, influencing tissue re…

    mechanotransductiontelocytesinterstitial cellsregeneration
  4. A
    2015

    Remodelling the extracellular matrix in development and disease

    Caroline Bonnans, Jonathan Chou, Zena Werb

    This narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…

    fasciaextracellular matrixstiffnessmechanotransductionmatrix remodeling
  5. 1A+
    2015

    Fascia and Primo Vascular System

    Chun Yang, Yi-kuan Du, Jian-bin Wu, JunWang, Ping Luan, Qin-lao Yang, Lin Yuan

    In this review article, the authors explore the idea that the body's network of fascia may be the physical structure corresponding to acupuncture meridians in Traditional Chinese Medicine (TCM). They also discuss the pr…

    fasciamechanotransductionprimo vascular systemBonghan systemfasciology
  6. A
    2014

    Fascia—Current knowledge and future directions in physiatry: Narrative review

    E H Kwong, T W Findley

    In this 2014 narrative review, the authors discuss fascia from the perspective of physiatry, or rehabilitation medicine. They note that while fascia is part of the body's connective tissue, its definition is unclear in…

    fasciaHyaluronic acidConnective tissuefibroblastmechanotransduction
  7. B
    2013

    CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts?

    Andrew Leask

    Mechanical tension is essential for the function and health of connective tissue. In skin fibroblasts, the protein integrin β1 plays a key role in adhesion and in regulating healing and fibrosis (scarring). This theoret…

    fibrosismechanotransductionIntegrinsCCN2CTGF