Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2021
Resveratrol Ameliorates Aortic Calcification in Ovariectomized Rats via SIRT1 Signaling
Sally K Hammad, Rana G Eissa, Mohamed A Shaheen, Nahla N YounisThis animal study on rats investigated how the phytoestrogen resveratrol affects aortic calcification following menopause. Researchers found that resveratrol, similar to estrogen, reduced calcium deposition in arterial…
SIRT1; estrogen; menopause; phytoestrogen; polyphenol; resveratrol; vascular calcification - A+++2021
Intermittent and periodic fasting, longevity and disease
Valter D Longo, Maira Di Tano, Mark P Mattson, Novella GuidiThis narrative review explores how intermittent fasting (IF) and periodic fasting (PF) may influence longevity and healthspan by acting on cellular aging processes. The authors describe how fasting periods ranging from…
fasting; fasting-mimicking diet; inflammation; intermittent fasting - A+++2021
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
Giulia Salvadori, Federica Zanardi, Fabio Iannelli, Riccardo Lobefaro, Claudio Vernieri, Valter D LongoThis study investigates how a fasting-mimicking diet (FMD) affects triple-negative breast cancer and its stem cells. Researchers found that FMD lowers blood glucose and inhibits growth signaling in cancer stem cells, wh…
CDK4/6; PI3K/AKT; PKA; cancer stem cells; fasting; fasting-mimicking diet; glucose; mTOR; starvation escape pathways; triple-negative breast cancer - A+++2021
The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors
Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye ChenThis study investigated the effects of fecal microbiota transplantation (FMT) on patients with diarrhea-predominant IBS (IBS-D) who also experience anxiety and depression. The results suggest that FMT may alleviate both…
Anxiety and depression; Fecal microbiota transplantation; Irritable bowel syndrome; Metagenome; Short-chain fatty acids - A+++2021
Cell-to-Cell Communication by Host-Released Extracellular Vesicles in the Gut: Implications in Health and Disease
Natalia Diaz-Garrido, Cecilia Cordero, Yenifer Olivo-Martinez, Josefa Badia, Laura BaldomàThis narrative review explores how small sacs called extracellular vesicles (EVs) act as messengers between cells in the gastrointestinal tract. These vesicles transport proteins, lipids, and genetic material that influ…
exosomes; extracellular vesicles; gut communication; gut immunity; intestinal homeostasis; miRNAs - A+++2021
Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome
Magdy El-Salhy, Jørgen Valeur, Trygve Hausken, Jan Gunnar HatlebakkThis clinical study investigated how fecal microbiota transplantation (FMT) affects short-chain fatty acids (SCFAs) in patients with irritable bowel syndrome (IBS). Researchers found that levels of butyric acid increase…
Fecal microbiota transplantationshort chain fatty acidsbutyric acidIrritable Bowel Syndrom - A+++2021
Direct impact of commonly used dietary emulsifiers on human gut microbiota
Sabrine Naimi, Emilie Viennois, Andrew T Gewirtz, Benoit ChassaingThis laboratory study examined how 20 common dietary emulsifiers affect human gut microbiota using an ex vivo model. The researchers found that several additives, particularly carrageenans and various gums, altered bact…
Dietary emulsifier; Gut microbiota; IBD; Intestinal inflammation - A+2021
Prevalence and risk factors for menopausal symptoms in middle-aged Chinese women: a community-based cross-sectional study
Xueyin Wang, Linhong Wang, Jiangli Di, Xiaosong Zhang, Gengli ZhaoThis community-based cross-sectional study examined the prevalence of menopausal symptoms among over 6,000 middle-aged Chinese women. The findings indicate that symptoms are most prevalent during the menopausal transiti…
Menopausal symptoms – Menopause – Perimenopause – Postmenopause – Risk factors - A+++2021
Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice
Beatriz Carmona-Hidalgo, Isabel González-Mariscal, Adela García-Martín, María E Prados, Francisco Ruiz-Pino, Giovanni A…This study investigated Δ9-tetrahydrocannabinolic acid (Δ9-THCA), the non-psychoactive precursor to THC, for its effects on liver fibrosis and inflammation in mice and cell cultures. The researchers found that Δ9-THCA r…
Fibrogenesis; Inflammation; Liver; NAFLD; Δ(9)-THCA - A+++2021
A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?
Hajra Khurshid, Israa A Qureshi, Nasrin Jahan, Terry R Went, Waleed Sultan, Alisha Sapkota, Michael AlfonsoThis systematic review explores the use of medicinal cannabis as a treatment for fibromyalgia, a condition characterized by chronic widespread pain, fatigue, and sleep disturbances. The researchers explain that fibromya…
alternative therapy; cannabinoids; cannabis; chronic pain; fibromyalgia; pharmacotherapy - A+++2021
Implementation Science Methodologies for Complementary and Integrative Health Research
David Clark, Emmeline Edwards, Peter Murray, Helene LangevinThis narrative review from the NCCIH describes the importance of implementation science in bridging the gap between clinical research and real-world medical practice. Even when therapies like acupuncture or yoga are sho…
complementary and integrative health; dissemination research; implementation science. - A+++2021
Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules
Qingqing Guo, Hao Lin, Pengcheng Chen, Songlin Tan, Zhiyong Wen, Lijian Lin, Jianquan He, Jianbo Wen, Shiyun LuThis randomized controlled trial investigated the effects of fecal microbiota transplantation (FMT) via oral capsules on patients with diarrhea-predominant IBS (IBS-D) and comorbid anxiety and depression. The findings s…
Diarrheal irritable bowel syndrome; anxiety and depression; bacterial community; fecal microbiota transplantation