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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–9 of 9 studiesmechanotransductionASince 2015
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  1. A
    2020

    Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation

    Andrew E Miller, Ping Hu, Thomas H Barker

    This narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…

    extracellular matrixstiffnesscytoskeletonmechanotransduction
  2. A
    2019

    Cellular nanoscale stiffness patterns governed by intracellular forces

    Nicola Mandriota, Claudia Friedsam, John A Jones-Molina, Kathleen V Tatem, Donald E Ingber, Ozgur Sahin

    Cell stiffness is important in many biological processes, but its precise relationship to the forces acting inside the cell has been unclear. In this study, researchers developed a new high-resolution imaging platform t…

    Tensegritymechanotransductioncell - cell interaction
  3. A
    2019

    Tissue Regeneration from Mechanical Stretching of Cell–Cell Adhesion

    Amir Monemian Esfahani, Jordan Rosenbohm, Keerthana Reddy, Xiaowei Jin, Tasneem Bouzid, Brandon Riehl, Eunju Kim, Jung…

    This narrative review explores how mechanical stretching can stimulate tissue regeneration and wound healing. Researchers have long known that cells respond to mechanical forces, but much of the focus has been on the co…

    wound healingmechanotransductioncell–cell adhesionmechanical stretchingtissue regeneration
  4. A
    2019

    Fascial Nomenclature: An Update

    Bruno Bordoni, Stevan Walkowski, Bruno Morabito, Matthew A Varacallo

    This review article discusses the ongoing challenge of creating a single, comprehensive definition for fascia. The authors argue that different scientific and clinical fields view fascia through their own unique lenses,…

    fasciamechanotransductionMyofascialOsteopathicphysiotherapy
  5. A
    2019

    The plasma membrane as a mechanochemical transducer

    Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs

    In this review article, researchers describe how the plasma membrane, the cell's outer boundary, acts as a key sensor for mechanical forces. The membrane senses and responds to physical stresses from its environment, su…

    mechanotransductionmechanosensorplasma membranemembrane tension
  6. A
    2019

    Mechanobiology of cells and cell systems, such as organoids

    Ece Bayir, Aylin Sendemir, Yannis F Missirlis

    This review discusses organoids, which are three-dimensional tissues grown in a lab that self-organize to mimic organ development. While organoids offer great potential for disease modeling and drug development, little…

    mechanotransductionmechanobiologyOrganoidMechanoepigeneticsCollective cell behavior
  7. A
    2019

    Biophysics of Cell-Substrate Interactions Under Shear

    Neha Paddillaya, Ashish Mishra, Paturu Kondaiah, Pramod Pullarkat, Gautam I Menon, Namrata Gundiah

    In this review article, the authors examine how cells adhere to surfaces and respond to mechanical forces. Cells use complex structures called focal adhesions to sense and react to their environment, including forces fr…

    mechanotransductionfocal adhesionsstress fibersshear stress and devicesbiophysical models
  8. A
    2018

    Fascial well-being: Mechanotransduction in manual and movement therapies

    Leon Chaitow

    This article discusses mechanotransduction, the process by which cells in connective tissue sense and respond to mechanical forces like stretch, compression, and shear. Specialized cells such as fibroblasts communicate…

    mechanotransduction
  9. A
    2015

    Remodelling the extracellular matrix in development and disease

    Caroline Bonnans, Jonathan Chou, Zena Werb

    This narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…

    fasciaextracellular matrixstiffnessmechanotransductionmatrix remodeling