Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2019
Anatomy, Fascia
Bruno Bordoni, Navid Mahabadi, Matthew VaracalloThis resource provides an overview of the anatomy of fascia. As the full text has not yet been reviewed, this summary is based on the title alone. The entry likely covers the structural and functional aspects of fascial…
fascia - A2019
The diaphragm muscle manual evaluation scale
Bruno Bordoni, Bruno MorabitoThis technical report describes a new method for manually assessing the diaphragm's function, called the Manual Evaluation Diaphragm (MED) scale. The scale is designed to generate a value for the respiratory muscle's mo…
fasciaMyofascialdiaphragmSurgeryphrenic nerve - A2019
Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor
Stephan Thönes, Sandra Rother, Tom Wippold, Joanna Blaszkiewicz, Kanagasabai Balamurugan, Stephanie Moeller, Gloria Rui…This study investigated a new type of hydrogel designed to improve wound healing. Researchers combined collagen and hyaluronan (HA), a natural component of connective tissue, with a growth factor that stimulates skin ce…
Biomimetic material; Extracellular matrix (ECM); Fibroblasts; Heparin-binding epidermal growth factor-like growth factor (HB-EGF); Hyaluronan; Hydrogel; Sulfated hyaluronan; Surface plasmon resonance; Wound healing. - A2019
Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model
S Azizi, A Farsinejad, R Kheirandish, H FatemiThis animal study investigated a potential treatment for osteoarthritis (OA) in rats. Researchers induced OA in the rats' knees and then treated them with intra-articular injections. One group received a combination of…
Osteoarthritis; SRGF; Monosodium iodoacetate; Vitamin C; Histopathology - A2019
Fascial Nomenclature: An Update
Bruno Bordoni, Stevan Walkowski, Bruno Morabito, Matthew A VaracalloThis review article discusses the ongoing challenge of creating a single, comprehensive definition for fascia. The authors argue that different scientific and clinical fields view fascia through their own unique lenses,…
fasciamechanotransductionMyofascialOsteopathicphysiotherapy - A2019
Glut-1 explains the evolutionary advantage of the loss of endogenous vitamin C-synthesis
Tabea C Hornung, Hans-Konrad BiesalskiUnlike many animals, humans cannot produce their own vitamin C. This study explores a potential evolutionary advantage of this loss. Researchers compared red blood cells from humans and pigs (who can make vitamin C) and…
glucose transporter; vitamin C; gulono-lactone-oxidase; vitamin C recycling - A2019
Active Contractile Properties of Fascia
ROBERT SCHLEIP, WERNER KLINGLERThis narrative review explores how fascia, often seen as a passive tissue, can actively contract. Researchers point to the presence of cells called myofibroblasts within the fascia, which give it the ability to change i…
myofibroblast; fascia; connective tissue; contracture; stiffness; fibrosis - A2019
Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes
Abigail McElroy, Ann Rashmir, Jane Manfredi, Dodd Sledge, Elizabeth Carr, Edward Stopa, Petra KlingeThis animal study investigated myodural bridges—connective tissue links between small neck muscles and the spinal cord's outer covering (dura mater)—in horses. Researchers compared horses with a genetic connective tissu…
Myodural BridgeEhlers-danlos syndromes - A2019
Where is your head? Perception of relative position of the head on a wielded object
Jeffrey B Wagman, Takahiro HiguchiThis study explored how we perceive our body's position relative to an object we are holding or balancing. Researchers specifically tested this by having participants "wield" an object with their head, a body part not t…
Haptics . Perception and action . Touch - A2019
Biotensegrity or Fascintegrity
Bruno Bordoni, Matthew A Varacallo, Bruno Morabito, Marta SimonelliIn this theoretical review, the authors question the popular "biotensegrity" model for describing the body's mechanics. They argue the model is incomplete because it fails to account for crucial factors like bodily flui…
fasciaMyofascialOsteopathicphysiotherapyskeletal muscle - A2019
Distinct fibroblast subsets drive inflammation and damage in arthritis
Adam P Croft, Joana Campos, Kathrin Jansen, Jason D Turner, Jennifer Marshall, Moustafa Attar, Loriane Savary, Corinna…This study in mice investigated the role of fibroblasts, a type of connective tissue cell, in arthritis. Researchers identified two distinct subsets of fibroblasts with different functions. One type, located in the syno…
Synovial fibroblasts; inflammation; arthritis; transcriptomics; rheumatoid arthritis - A2019
High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
Ling-Hui Zeng, Qing-Mei Wang, Lin-Yi Feng, Yu-Dun Ke, Qian-Zi Xu, An-Yi Wei, Chong Zhang, Rong-Biao YingThis study on breast cancer cells in the lab and in mice explored how different doses of vitamin C affect cancer cell behavior. Researchers found that low and medium doses of vitamin C seemed to encourage cancer cells t…
Breast cancermetastasisTGF-β1Vitamin C