Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2015
Evidence for the existence of nociceptors in rat thoracolumbar fascia
S Mense, U HoheiselThis animal study on rats investigated the presence of pain-sensing nerve fibers (nociceptors) in the thoracolumbar fascia. Researchers compared normal fascia with tissue in which they had induced inflammation. The resu…
inflammationfasciafasciitisnon-specific low back painfascia nociceptors - A2015
Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes
Jun Tian, Yan LiLocal anesthetics injected into joints can sometimes be harmful to cartilage cells (chondrocytes). This laboratory study investigated the effects of three common anesthetics—ropivacaine, bupivacaine, and lidocaine—on hu…
Chondrocytes; Vitamin C; Local anesthetics; Ropivacaine; Bupivacaine; Lidocaine - A2015
Collagen network strengthening following cyclic tensile loading
Monica E Susilo, Jeffrey A Paten, Edward A Sander, Thao D Nguyen, Jeffrey W RubertiTissues adapt to the mechanical loads they experience, with collagen being the primary load-bearing component. In this study, researchers investigated how a collagen-based material responded to repeated, cyclic tensile…
collagen networkmechanical adaptationtissue remodelling - A2015
Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels
Sanda Maria Cretoiu, Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Dragos Cretoiu, Laura Cristina Ceafala…Telocytes are a relatively newly described cell type found in the muscular wall of the uterus, thought to play a role in cell-to-cell signaling. In this laboratory study, researchers examined telocytes from both pregnan…
Telocytes · Human myometrium · T-type calcium channels · CaV3.1 · CaV3.2 - A2015
Hyaluronan, inflammation and breast cancer progression
Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthyThis narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…
hyaluronaninflammationCD44fasciaBreast cancer - A2015
Pathophysiology and Immune Dysfunction in Endometriosis
Soo Hyun Ahn, Stephany P Monsanto, Caragh Miller, Sukhbir S Singh, Richard Thomas, Chandrakant TayadeThis narrative review explores the current understanding of endometriosis, a chronic inflammatory condition affecting many women of reproductive age. The authors focus on how endometriosis lesions develop a blood supply…
endometriosis - A2015
Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer
Jirí Pokorný, Jan Pokorný, Alberto Foletti, Jitka Kobilková, Jan Vrba, Jan Vrba JrThis theoretical paper explores the link between cellular energy and cancer. Healthy cells maintain a stable, coherent electrical state through continuous energy production in the mitochondria. The authors propose that…
fasciacancer biophysicsmitochondrial dysfunctionwater orderingmicrotubule oscillations - A2015
The content and size of hyaluronan in biological fluids and tissues
Mary K Cowman, Hong-Gee Lee, Kathryn L Schwertfeger, James B McCarthy,, Eva A TurleyHyaluronan is a simple sugar polymer found throughout the body's tissues and fluids. It is typically produced as a very large, high-molecular-mass molecule. This narrative review notes that during processes like inflamm…
hyaluronanfasciaquantificationassaymolecular mass - A2015
Reflections on osteopathic fascia treatment in the peripheral nervous system
Bruno Bordoni, Giovanni BordoniIn this reflective article, the authors discuss the fascia of the peripheral nervous system. They explain that nerves are enclosed in several layers of fascia that must be able to slide, and that impeded sliding can be…
fasciapainfascial treatmentnerve palpation - A2015
Modes of cancer cell invasion and the role of the microenvironment
Andrew G Clark, Danijela Matic VignjevicFor cancer to spread, or metastasize, tumor cells must first invade the surrounding connective tissue (stroma). This review article describes how cancer cells can move in different ways—either as single cells or in coll…
fasciaextracellular matrixcancertumor invasionmicroenvironment - A2015
Primo Vascular System: A Unique Biological System Shifting a Medical Paradigm
Bruno Chikly, Paul Roberts, Jörgen QuaghebeurThis article describes the primo vascular system (PVS), a unique biological system distinct from the arteriovenous and lymphatic systems. Research suggests the PVS has immune and endocrine functions and plays a role in…
fasciaprimo vascular system - A2015
A multidisciplinary approach to scars: a narrative review
Emiliano Zanier, Bruno BordoniThis narrative review examines complementary and alternative medicine approaches to treating scar tissue. The authors survey literature on osteopathy, naturopathy, and manual therapies like physiotherapy. They also disc…
fasciaosteopathyscarwoundcomplementary and alternative medicine