Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2016
Hyaluronan production and molecular weight is enhanced in pathway-engineered strains of lactate dehydrogenase-deficient Lactococcus lactis
Mandeep Kaur, Guhan JayaramanResearchers are exploring ways to use engineered bacteria to produce hyaluronic acid (HA), but the yield and molecular weight have often been limited. Previous work suggested that excessive lactate production might be t…
Hyaluronic acid molecular weightLactococcus lactisLactate dehydrogenase mutantNADþ/NADH ratioHA-precursor concentration ratio - A2016
Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells
Renaud Massart, Sergiy Dymov, Magali Millecamps, Matthew Suderman, Stephanie Gregoire, Kevin Koenigs, Sebastian Alvarad…In this animal study, researchers investigated how chronic pain might be linked to epigenetic changes, specifically DNA methylation. They compared rats with long-term nerve injury pain to a control group, examining tiss…
immune systemchronic painCentral nervous systemcortexDNA methylation - A2016
Monitoring the primo vascular system in lymphatic vessels by using window chambers
Jungdae Kim, Dong-Hyun Kim, Sharon Jiyoon Jung, Hyun-Ji Gil, Seung Zhoo Yoon, Young-Il Kim, Kwang-Sup SohIn this animal study, researchers developed a method for observing the primo vascular system (PVS) inside the lymphatic vessels of rats over an extended period. By implanting a "window chamber" into the skin and injecti…
primo vascular systemlymphatic vessels - A2016
Connection of the Posterior Occipital Muscle and Dura Mater of the Siamese Crocodile
JING-HUI ZHANG, WEI TANG, ZHAO-XI ZHANG, BING-YI LUAN, SHENG-BO YU, HONG-JIN SUIIn this animal study, researchers investigated a connective tissue structure called the myodural bridge in six Siamese crocodiles. This bridge connects deep muscles in the suboccipital region to the dura mater, the oute…
myodural bridge; rectus capitis posterior major muscle; rectus capitis posterior minor muscle;proatlas; spinal dura mater; Siamese crocodile; cerebrospinal fluid circulation - A2016
Fascial Manipulation Associated With Standard Care Compared to Only Standard Postsurgical Care for Total Hip Arthroplasty: A Randomized Controlled Trial
Massimo Busato, Cristian Quagliati, Lara Magri, Alessandra Filippi, Alberto Sanna, Mirco Branchini, Aurelie Marie March…This randomized controlled trial investigated the effects of adding Fascial Manipulation (FM) to standard rehabilitation after total hip replacement surgery. Researchers divided 51 patients into two groups: one received…
Fascial manipulationHip arthroplasty - A2016
Telocytes and Their Extracellular Vesicles—Evidence and Hypotheses
Dragos Cretoiu, Jiahong Xu, Junjie Xiao, Sanda M CretoiuThis narrative review discusses telocytes, a relatively new type of interstitial cell found throughout the body's connective tissues. These cells are characterized by long projections and are involved in communication b…
telocytes; telopodes; extracellular vesicles; exosomes; ectosomes - A2016
Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase
Sebastian Kalamajski, Dominique Bihan, Arkadiusz Bonna, Kristofer Rubin, Richard W FarndaleFibrosis is characterized by a dense and stiff collagen matrix, formed through a cross-linking process driven by the enzyme lysyl oxidase (LOX). This study investigated the role of another protein, fibromodulin, in this…
fibrosiscollagen cross-linkingfibromodulinlysyl oxidase - A2016
Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain
David M Klyne, Mary F Barbe, Paul W HodgesThis study investigated systemic inflammation in acute low back pain, which is less studied than inflammation in chronic conditions. Researchers analyzed blood samples from 99 individuals within two weeks of LBP onset a…
Pro-inflammatory cytokinesC-reactive protein (CRP)Interleukin-6 (IL-6)Tumor necrosis factor (TNF)Interleukin-1beta (IL-1beta) - A2016
Restoration of Full Shoulder Range of Motion After Application of the Fascial Distortion Model
Joshua D Boucher, Jose FigueroaThis case report describes a 28-year-old man with chronic shoulder pain and severely limited movement, 18 months after an injury. His condition, similar to a frozen shoulder, involved significant pain and an inability t…
frozen shoulderfascial distortion modelrange of motion - A2016
Cystocele and functional anatomy of the pelvic floor: review and update of the various theories
Géry Lamblin, Emmanuel Delorme, Michel Cosson, Chrystèle RubodThis narrative review examines different anatomical theories about how the pelvic floor supports the bladder. The researchers summarize that this support involves a complex interplay of the pubocervical fascia, endopelv…
Pelvic floor . Cystocele . Connective tissue . Anatomy . Endopelvic fascia . Pelvic mobility - A2015
Remodelling the extracellular matrix in development and disease
Caroline Bonnans, Jonathan Chou, Zena WerbThis narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…
fasciaextracellular matrixstiffnessmechanotransductionmatrix remodeling - A2015
Investigation of meningomyovertebral structures within the upper cervical epidural space: a sheet plastination study with clinical implications
Frank Scali, Matthew E Pontell, Lance G Nash, Dennis E EnixThis cadaver study investigated soft-tissue connections within the epidural space of the upper cervical spine using dissection and a technique called sheet plastination. The researchers found consistent connections wher…
fasciacervical spineMyodural Bridgedural lacerationsepidural space