Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A++2013
Mathematical Analysis of the Flow of Hyaluronic Acid Around Fascia During Manual Therapy Motions
Max Roman, Hans Chaudhry, Bruce Bukiet, Antonio Stecco,Thomas FindleyThis study used a mathematical model to simulate how different manual therapy techniques affect the flow of hyaluronic acid (HA) within fascia. The researchers compared constant sliding, perpendicular vibration, and tan…
hyaluronanfasciaManual Therapyfluid flowvibration - A++2013
Vibration Induced Osteogenic Commitment of Mesenchymal Stem Cells is Enhanced by Cytoskeletal Remodeling but not Fluid Shear
Gunes Uzer, Suphannee Pongkitwitoon, M Ete Chan, Stefan JudexThis laboratory study investigated how mechanical vibrations encourage stem cells to develop into bone cells. Researchers tested two potential mechanisms: the force of fluid moving across the cells (fluid shear) and cha…
fasciaBonedifferentiationProliferationvibrations - A++2013
The application of matrix rhythm therapy as a new clinical modality in burn physiotherapy programmes
Zübeyir Sarı, Mine Gülden Polat, Bahar Özgül, Onur Aydogdu, Burcu Camcıoglu, Ahmet Hakan Acar, Saadet Ufuk YurdalanThis study investigated the use of Matrix Rhythm Therapy (MRT) as part of a physiotherapy program for patients with upper extremity burn injuries. A group of patients received a treatment protocol that included whirlpoo…
Matrix Rhythm TherapyBurnsPhysiotherapy and rehabilitation - A++2012
Vitamin C transport and its role in the central nervous system
James M MayThis review article explores the critical role of vitamin C in the central nervous system. Although it circulates in the blood at low concentrations, neurons in the brain and spinal cord maintain very high levels of the…
ascorbate transport; brain; dehydroascorbate; glutamate; neurons; SVCT2 - A++2012
Discovering the link between nutrition and skin aging
Silke K Schagen, Vasiliki A Zampeli, Evgenia Makrantonaki, Christos C ZouboulisThis narrative review examines the relationship between nutrition and skin aging, focusing on how specific nutrients may protect against damage from ultraviolet (UV) radiation. The authors describe how antioxidants such…
antioxidants; diet; fatty acids; flavonoids; nutrition; skin aging; ultraviolet protection; vitamins. - A++2012
INTERSTITIAL FLUID AND LYMPH FORMATION AND TRANSPORT: PHYSIOLOGICAL REGULATION AND ROLES IN INFLAMMATION AND CANCER
Helge Wiig, Melody A SwartzThis 2012 review explores the interstitium, the fluid-filled space surrounding our cells that contains interstitial fluid (IF). Formed by filtration from blood capillaries and cleared by lymphatic vessels, IF and its fl…
ImmunologyLymphTumorinterstitiumfluid - A++2012
Fluid Flow along Venous Adventitia in Rabbits: Is It a Potential Drainage System Complementary to Vascular Circulations?
Hong-yi Li, Min Chen, Jie-fu Yang, Chong-qing Yang, Liang Xu, Fang Wang, Jia-bin Tong, You Lv, Caidan SuonanIn this animal study on rabbits, researchers investigated a potential fluid drainage system within the body's connective tissue. By injecting tracers, they visualized pathways along the loose connective tissue surroundi…
interstitial fluidacupuncturefluid flow - A++2012
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease
Kirsty Brown, Daniella DeCoffe, Erin Molcan, Deanna L GibsonThis 2012 narrative review explores the connection between diet, gut microbes, and the immune system. The gastrointestinal tract must balance tolerance for harmless bacteria and food with responsiveness to pathogens. An…
inflammationnutritionintestinal microbiotadisease susceptibility - A++2012
Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
Melody A Swartz, Amanda W LundThis review explores how tumors interact with the lymphatic system to grow and spread. Increased fluid flow from a tumor to nearby lymph nodes does more than just transport cancer cells. This flow also creates mechanica…
fasciacancerstiffnessmechanobiologymicroenvironment - A++2011
Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?
Whitney P Bowe, Alan C LoganThis review article discusses a theory first proposed over 70 years ago connecting the gastrointestinal tract, the brain, and the skin. Researchers Stokes and Pillsbury hypothesized that emotional states like anxiety an…
acneprobioticsintestinal microfloragut-brain-skinbacteriotherapy - A++2011
Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments
Jennifer Z Paxton, Paul Hagerty, Jonathan J Andrick, Keith BaarThis study on engineered ligaments explored how different stretching patterns affect tissue development. Researchers used a bioreactor to apply cyclic stretch, measuring cellular responses by tracking a key protein call…
collagen synthesisERK 1/2 phosphorylationintermittent stretch - A++2011
Review of Evidence Suggesting That the Fascia Network Could Be the Anatomical Basis for Acupoints and Meridians in the Human Body
Yu Bai, Jun Wang, Jin-Peng Wu, Jing-Xing Dai, Ou Sha, David Tai Wai Yew, Lin Yuan, Qiu-Ni LiangThis narrative review explores the idea that the body's fascia network could be the physical structure behind traditional Chinese medicine's (TCM) meridians and acupoints. The authors examine anatomical, physiological,…
fasciaacupunctureacupoints