Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A++2014
New perspective in cell communication: Potential role of ultra-weak photon emission
Ankush Prasad, Claudio Rossi, Stefania Lamponi, Pavel Pospíšil, Alberto FolettiThis 2014 narrative review explores how cells might communicate with each other. Beyond chemical signals and direct contact, the authors discuss evidence for communication via electromagnetic radiation, specifically ult…
fasciabiophotonsUltra-weak photon emissioncellular interactionbiocommunication - A++2014
The role of collagen crosslinks in ageing and diabetes - the good, the bad, and the ugly
Jess G Snedeker, Alfonso GautieriThis narrative review explores how glucose in the body can bind to proteins like collagen, a process called glycation. This process creates crosslinks that can change the mechanical properties and function of connective…
collagenCrosslinksageingadvanced glycation endproductstendon mechanics - A++2014
Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products
Alfonso Gautieri, Alberto Redaelli, Markus J Buehler, Simone VesentiniAdvanced Glycation End-products (AGEs) are harmful crosslinks that form in collagen with aging and in diabetes, making tissues stiffer. However, the exact location of these crosslinks has been unclear. In this theoretic…
Advanced glycation end-products; Ageing; Atomistic simulations; Collagen; Crosslinks; Diabetes. - A++2014
Antioxidants, inflammation and cardiovascular disease
Harald Mangge, Kathrin Becker, Dietmar Fuchs, Johanna M GostnerThis narrative review explores the links between inflammation, oxidative stress, and cardiovascular disease (CVD). The authors explain that chronic immune activation in CVD leads to high levels of reactive oxygen specie…
Antioxidative therapy; Atherogenesis; Cardiovascular disease; Homocysteine; Neopterin; Nitric oxide; Oxidative stress; Tetrahydrobiopterin; Tryptophan; Vitamins. - A++2014
Role of reactive oxygen species in ultra-weak photon emission in biological systems
Pavel Pospíšil, Ankush Prasad, Marek RácThis narrative review explores the connection between reactive oxygen species (ROS) and the faint light, or ultra-weak photon emission, that living organisms naturally produce. The authors explain that normal metabolic…
biophotonsChemiluminescenceReactive oxygen specieslipid peroxidationHydroxyl radical - A++2014
Vibration therapy: clinical applications in bone
William R Thompson, Sherwin S Yen, Janet RubinThis review article explores vibration therapy as a way to mimic the positive effects of physical activity on bone and muscle, especially for frail individuals who cannot exercise. Animal and human studies suggest that…
low-intensity vibration; mesenchymal stem cells; osteocyte; osteoporosis - A++2013
Air ions and mood outcomes: a review and meta-analysis
Vanessa Perez, Dominik D Alexander, William H BaileyThis review and meta-analysis examined 33 studies to investigate how air ions affect human psychological states. The authors found no consistent effects of positive or negative ionization on anxiety, general mood, relax…
systematic reviewepidemiologyMood disordersDepressionAir ionization - A++2013
Vitamin C in Disease Prevention and Cure: An Overview
Shailja Chambial, Shailendra Dwivedi, Kamla Kant Shukla, Placheril J John, Praveen SharmaThis narrative review provides an overview of Vitamin C's many roles in the body. It is essential for developing and maintaining connective tissues, and plays a key part in bone formation, wound healing, and gum health.…
cancerdiabetesVitamin CImmunityinfertility - A++2013
Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin-C deficient mice
John Cha, M Waheed Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias RathThis animal study investigated how Vitamin C (ascorbate) supplementation affects cancer growth in mice that, like humans, cannot produce their own. Researchers injected melanoma or breast cancer cells into two groups of…
Tumor growthinterleukin-6apoptosismetastasisascorbate - A++2013
Squeeze film lubrication for non-Newtonian fluids with application to manual medicine
Hans Chaudhry, Bruce Bukiet, Max Roman, Antonio Stecco, Thomas FindleyResearchers used a mathematical model to investigate how manual therapy affects the fluid in and around fascia. The model focused on hyaluronic acid (HA), a natural lubricant in connective tissue. The results suggest th…
fasciaHyaluronic acidmassage therapyvibrationsmanual manipulation - A++2013
Implementation of Matrix Rhythm Therapy and Conventional Massage in Young Females and Comparison of Their Acute Effects on Circulation
Ferruh Taspinar, Ummuhan Bas Aslan, Nuran Sabir, Ugur CavlakThis randomized controlled trial compared the acute effects of Matrix Rhythm Therapy and conventional massage on lower leg blood circulation in young, healthy women. Fifteen participants received a single 30-minute sess…
fascia - A++2013
Cell-to-cell signaling through light: just a ghost of chance?
Ondřej Kučera, Michal CifraThis paper examines the physical feasibility of cell-to-cell communication via weak light signals, often referred to as biophotons. The researchers analyze whether electromagnetic signaling is possible when considering…
Cell signalingbiophotonsphoton emission