Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Gut Microbiota and Cardiovascular Disease
Marco Witkowski, Taylor L Weeks, Stanley L HazenThis review explores how the gut microbiota influences cardiovascular health through the production of specific metabolic byproducts. Research suggests that the link is not merely associative; certain bacterial metaboli…
atherosclerosis; cardiovascular diseases; gastrointestinal microbiome; thrombosis; vascular diseases - A+++2020
The immediate effect of IASTM vs. Vibration vs. Light Hand Massage on knee angle repositioning accuracy and hamstrings flexibility: A pilot study
George A Koumantakis, Eleonora Roussou, Georgios A Angoules, Nikolaos A Angoules, Theodoros Alexandropoulos, Georgia Ma…This pilot study compared the immediate effects of three different soft tissue techniques on the hamstrings of 16 healthy men. The techniques were instrument-assisted soft tissue mobilization (IASTM), vibration massage,…
fasciaproprioceptionMassageMuscle tightness - A+++2020
Prevention and treatment of COVID-19 infection by earthing
Haider Abdul-Lateef MousaThis observational study investigated the effects of 'earthing'—direct physical contact with the ground—in 59 people with COVID-19. Participants engaged in earthing for 15 minutes to 3 hours daily. The author reported t…
COVID-19; COVID-19 treatment; COVID-19 prevention; Earthing; Grounding; cytokine storm - A+++2020
The role of cannabinoids in the treatment of cancer
L Vecera, T Gabrhelik, P Prasil, P StouracThis review article summarizes current knowledge on how cannabinoids and their receptors modulate tumor diseases. Research suggests that cannabinoids may influence cancer progression by stimulating programmed cell death…
cancer; cannabinoid receptor; cannabinoids; oncological diseases cancer treatment - A+++2020
A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and "Medical Cannabinoids"
Renáta Szabó, Denise Börzsei, Zsuzsanna Szabó, Alexandra Hoffmann, István Zupkó, Dániel Priksz, Krisztina Kupai, Csaba…This animal study using an estrogen-deficient rat model investigated how the endocannabinoid anandamide (AEA) affects cardiovascular health during menopause-like conditions. Researchers found that estrogen loss reduced…
anandamide; cardiovascular system; heme oxygenase; nitric oxide synthase - A+++2020
Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis 24-month randomized controlled crossover trial investigated the effects of daily resveratrol supplementation in 125 postmenopausal women. The findings suggest that taking 75 mg of resveratrol twice daily may reduce…
Resveratrolpolyphenolemenopause - A+++2020
Propolis-induced exclusion of colloids: Possible new mechanism of biological action
Magdalena Kowacz, Gerald H PollackThis laboratory study investigates how propolis (bee glue) interacts with water to create an exclusion zone (EZ)—a layer of water that repels solutes and microorganisms. The researchers found that surfaces coated with p…
Colloid-surface repulsion; Exclusion zone; Propolis - A+++2020
A Closer Look at Anandamide Interaction With TRPV1
Chante Muller, Diane L Lynch, Dow P Hurst, Patricia H ReggioThis study used advanced molecular dynamics simulations to investigate how anandamide, an endocannabinoid, interacts with the TRPV1 ion channel, which is central to pain perception. The researchers observed that anandam…
TRP channels; TRPV1; anandamide; cannabinoids; molecular dynamics - A+++2020
Mechanical stimulation of human dermal fibroblasts regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies
Aric Anloague, Aaron Mahoney, Oladipupo Ogunbekun, Taylor A Hiland, William R Thompson, Bryan Larsen, M Terry Loghmani,…This lab study investigated how mechanical forces, similar to those in manual therapy, affect human skin cells. Researchers first applied a repetitive strain to cultured dermal fibroblasts to simulate an overuse injury,…
inflammationMyofascial releaseManual Therapyphysical therapyphysiotherapy - A+++2020
Om vikten av att stärka immunförsvaret under covid-19
Mats Humble, Bo Jonsson, Per KågesonThis memo summarizes the state of knowledge on strengthening the immune system in the elderly to better manage COVID-19. The authors focus on findings that highlight the importance of maintaining adequate levels of spec…
VitaminsImmune system - A+++2020
Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled Trials
Josefine Nelson, Helen Sjöblom, Inger Gjertsson, Stine M Ulven, Helen M Lindqvist, Linnea BärebringThis systematic review examined randomized controlled trials to determine if diet or dietary supplements can reduce disease activity in adults with rheumatoid arthritis. The researchers found moderate-strength evidence…
DAS28; Rheumatoid Arthritis; diet - A+++2020
Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles
Piero Pavan, Elena Monti, Michela Bondí, Chenglei Fan, Carla Stecco, Marco Narici, Carlo Reggiani, Lorenzo MarcucciThis study investigated why muscles become stiffer with age by comparing individual muscle fibers to bundles of fibers that include the extracellular matrix (ECM). Researchers found that while the stiffness of individua…
aging; collagen; extracellular matrix; resting tension; single muscle fiber; skeletal muscle.