Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2021
Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin
Edwin D Lephart, Frederick NaftolinThis narrative review explores how the decline in estrogen levels during menopause significantly impacts skin health and structural integrity. The loss of estrogen leads to reduced collagen and elastin production, along…
4′-Acetoxy resveratrol; Aging; Cosmeceuticals; Equol; Estrogen; Estrogen deficient skin; Hormone therapy; Menopause; Polyphenols; Skin - A+++2021
Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression
Harriet Emma Clare Sharp, Hugo D Critchley, Jessica A EcclesThis narrative review explores the growing evidence linking joint hypermobility, a common connective tissue variant, with a range of psychiatric conditions. The authors summarize the well-established connection to anxie…
Hypermobile Ehlers-Danlos syndrome; Joint hypermobility; Mind-body relations; Neurodevelopmental disorders; Psychiatric disorders; Psychopathology. - A+++2021
Estrogenic Effect of Salvia officinalis Extract on Reproductive Function of Female Mice and Identification of Its Phenolic Content
Sabah H Elgayed, Elham A Afify, Hanan A Amin, Ahmed A H AbdellatifThis animal study on mice investigated whether sage (Salvia officinalis) extract could serve as a natural alternative to estrogen replacement therapy. Researchers found that sage contains phytoestrogens, specifically qu…
Natural phytoestrogens; female mice.; menopause; natural estrogen; phenolic content; saliva officinalis; uterotrophic activity - A+++2021
Intermittent and periodic fasting, longevity and disease
Valter D Longo, Maira Di Tano, Mark P Mattson, Novella GuidiThis narrative review explores how intermittent fasting (IF) and periodic fasting (PF) may influence longevity and healthspan by acting on cellular aging processes. The authors describe how fasting periods ranging from…
fasting; fasting-mimicking diet; inflammation; intermittent fasting - A+++2021
Fascial thickness and stiffness in hypermobile Ehlers-Danlos syndrome
Tina J Wang, Antonio SteccoResearchers investigated fascial changes in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a condition often associated with widespread pain. They used ultrasound and elastography to compare fascial thickness an…
deep fasciaconnective tissue disorderhypermobile Ehlers-Danlos syndromeultrasound elastography - A+++2021
The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self
Wen G Chen, Dana Schloesser, Angela M Arensdorf, Janine M Simmons, Changhai Cui, Rita Valentino, James W Gnadt, Lisbeth…This review article presents a unified framework for interoception, the process by which the body senses, interprets, and regulates its internal signals. The authors propose an expanded definition that includes bidirect…
autonomic; insula; parasympathetic; spinal; sympathetic; vagal - A+++2021
Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome
Magdy El-Salhy, Jørgen Valeur, Trygve Hausken, Jan Gunnar HatlebakkThis clinical study investigated how fecal microbiota transplantation (FMT) affects short-chain fatty acids (SCFAs) in patients with irritable bowel syndrome (IBS). Researchers found that levels of butyric acid increase…
Fecal microbiota transplantationshort chain fatty acidsbutyric acidIrritable Bowel Syndrom - A+++2021
Gut Microbiota Extracellular Vesicles as Signaling Molecules Mediating Host-Microbiota Communications
Salma Sultan, Walid Mottawea, JuDong Yeo, Riadh HammamiThis review article discusses how small membrane-bound sacs called microbiota-released extracellular vesicles (MEVs) act as messengers between the gut microbiome and the host body. These vesicles carry a variety of biol…
gut microbiota; gut microbiota-brain axis; microbial metabolites; microbiota extracellular vesicles; microbiota-host communications; molecular signalling - A+++2020
A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and "Medical Cannabinoids"
Renáta Szabó, Denise Börzsei, Zsuzsanna Szabó, Alexandra Hoffmann, István Zupkó, Dániel Priksz, Krisztina Kupai, Csaba…This animal study using an estrogen-deficient rat model investigated how the endocannabinoid anandamide (AEA) affects cardiovascular health during menopause-like conditions. Researchers found that estrogen loss reduced…
anandamide; cardiovascular system; heme oxygenase; nitric oxide synthase - A+++2020
Movement Caused by Electrical Stimulation of the Lumbosacral Region in Standing Horses
Daniela C Riedler, Rebeka R Zsoldos, Matthias Robel, Isabelle D Jobst, Theresia F LickaThis study investigated how electrical stimulation (ES) affects movement in the lower back and pelvis of standing horses compared to manual techniques. While both methods successfully triggered movement in the lumbosacr…
Electrical stimulation; Lumbosacral; Pelvic inclination; Physical therapy; Sacroiliac - A+++2020
Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
Wresti L Anggayasti, Chikahiro Imashiro, Taiki Kuribara, Kiichiro Totani, Kenjiro TakemuraResearchers are exploring mechanical vibration as a potential cancer therapy that avoids harming healthy cells. In this lab study, a brief, low-frequency vibration was applied to a line of human skin cancer cells (A431)…
apoptosismechanical vibrationcancer cell modelglucose metabolismhigh-mobility group box 1 - A+++2020
Propolis-induced exclusion of colloids: Possible new mechanism of biological action
Magdalena Kowacz, Gerald H PollackThis laboratory study investigates how propolis (bee glue) interacts with water to create an exclusion zone (EZ)—a layer of water that repels solutes and microorganisms. The researchers found that surfaces coated with p…
Colloid-surface repulsion; Exclusion zone; Propolis