Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Zachary M Harvanek, Nia Fogelman, Ke Xu, Rajita SinhaChronic stress is linked to negative health outcomes, and this study explored its connection to accelerated biological aging. Researchers evaluated 444 adults, measuring their cumulative stress, biological age using an…
AgingStresspsychological morbidityanxityepigenetic - A+++2021
The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self
Wen G Chen, Dana Schloesser, Angela M Arensdorf, Janine M Simmons, Changhai Cui, Rita Valentino, James W Gnadt, Lisbeth…This review article presents a unified framework for interoception, the process by which the body senses, interprets, and regulates its internal signals. The authors propose an expanded definition that includes bidirect…
autonomic; insula; parasympathetic; spinal; sympathetic; vagal - A+++2021
Soft Tissue Manipulation May Attenuate Inflammation, Modulate Pain, and Improve Gait in Conscious Rodents With Induced Low Back Pain
M Terry Loghmani, Carolyn Tobin, Colleen Quigley, Alanna FennimoreThis animal study on rodents explored how instrument-assisted soft tissue manipulation (IASTM) affects pain, gait, and inflammation in cases of low back pain. The researchers found that the treatment suggests an ability…
rehabilitation - A+++2021
Nutrition Provides the Essential Foundation for Optimizing Mental Health
Julia J Rucklidge, Jeanette M Johnstone, Bonnie J KaplanThis review article explores the critical link between nutrition and mental health, written to guide psychologists in their clinical practice. The authors outline how a whole-foods diet supports brain function through v…
Vitamins; minerals; nutrition; nutrients; treatment; mental health - A+++2021
Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype
Cristina Ferreira Almeida, Natércia Teixeira, Georgina Correia-da-Silva, Cristina AmaralThis narrative review explores how different subtypes of breast cancer respond to cannabinoids like THC and CBD. Research suggests that estrogen receptor-negative cells may be more susceptible to these compounds than ho…
Cannabis sativa; anandamide; breast cancer; cannabidiol; cannabidivarin; cannabigerol; cannabinoids; cannabinol; Δ9-tetrahydrocannabinol - A+++2021
Resveratrol Ameliorates Aortic Calcification in Ovariectomized Rats via SIRT1 Signaling
Sally K Hammad, Rana G Eissa, Mohamed A Shaheen, Nahla N YounisThis animal study on rats investigated how the phytoestrogen resveratrol affects aortic calcification following menopause. Researchers found that resveratrol, similar to estrogen, reduced calcium deposition in arterial…
SIRT1; estrogen; menopause; phytoestrogen; polyphenol; resveratrol; vascular calcification - A+++2021
Effect of vibration therapy on physical function in critically ill adults (VTICIA trial): protocol for a single-blinded randomised controlled trial
Nobuto Nakanishi, Satoshi Doi, Yoshimi Kawahara, Mie Shiraishi, Jun OtoThis is a protocol for a randomized controlled trial designed to investigate the effect of vibration therapy for critically ill adults. The researchers plan to enroll 188 intensive care unit (ICU) patients and randomly…
vibration therapydeliriummuscle atrophy - A+++2021
The challenges of chronic pain and fatigue
Jessica A Eccles, Kevin A DaviesIn this review article, the authors explore the challenges of chronic pain and fatigue, two common and frequently overlapping symptoms. They discuss possible underlying biological associations, including connective tiss…
Fibromyalgiapainfatiguehypermobilityrheumatology - A+++2021
Hyaluronan and the Fascial Frontier
Rebecca L PrattThis narrative review explores the role of hyaluronan (HA) in the body's fascial system. HA is a key component of the extracellular matrix, widely used in products from skin creams to joint injections for its ability to…
HA; connective tissue; densification; extracellular matrix; fascia; fasciacyte; gliding; hyaluronan; hyaluronic acid; myofascial pain. - A+++2021
Myofascial pain in females and personalized care: The key role played by sex hormones
Caterina Fede, Carmelo Pirri, Raffaele De Caro, Carla SteccoBased on its title, this publication appears to explore the relationship between sex hormones and myofascial pain specifically in females. The authors suggest that hormonal factors play a key role in this type of pain.…
Myofascial painsex hormonesfemales - A+++2021
Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism
Brian Tuckey, John Srbely, Grant Rigney, Meena Vythilingam, Jay ShahIn this theoretical paper, the authors propose a potential mechanism for chronic pain syndromes. They hypothesize that impaired lymphatic drainage following trauma or an immune response can trap inflammatory substances…
fasciacytokinesinterstitial inflammatory stasislymphatic dysfunctioncounterstrain techniques - A+++2021
Low frequency weak electric fields can induce structural changes in water
Iman Rad, Rainer Stahlberg, Kurt Kung, Gerald H PollackThis study investigated how weak, low-frequency electric fields affect the structure of different types of water, including "exclusion zone" (EZ) water. Researchers found that exposure to these fields, even without dire…
EZ waterfourth phase of water