Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2019
Tentorium Cerebelli: the Bridge Between the Central and Peripheral Nervous System, Part 2
Bruno Bordoni, Marta Simonelli, Maria Marcella LaganaThis article, the second in a series, describes the tentorium cerebelli—a meningeal structure related to the skull, nervous system, and cervical spine. The authors discuss its complex relationships, including its neurol…
fasciapaincraniotentorium cerebellivenous circulation - A+++2019
The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma
Francesca Rossi, Chiara Tortora, Francesca Punzo, Giulia Bellini, Maura Argenziano, Alessandra Di Paola, Marco Torella,…Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) system's receptors are the cannabinoid receptor…
CB1; CB2; TRPV1; bone; osteoblasts; osteoclasts; osteoporosis; osteosarcoma - A+++2019
Vitamin C: an essential “stress hormone” during sepsis
Paul E MarikThe body's stress response involves hormones like cortisol and catecholamines, but in most mammals, it also includes increased production of vitamin C. These substances work together to protect the body from damage duri…
Sepsis; vitamin C; HPA axis; stress response - A+++2019
A comparative multi-site and whole-body assessment of fascia in the horse and dog: a detailed histological investigation
Waqas Ahmed, Marta Kulikowska, Trine Ahlmann, Lise C Berg, Adrian P Harrison, Vibeke Sødring ElbrøndThis animal study compared the microscopic structure of fascia in horses and dogs across multiple body regions. Researchers found that horse fascia is generally tight and dense, while dog fascia is looser and more simil…
deep fascia; dog; histology; horse; hypodermis; myofascial kinetic lines; superficial fascia. - A+++2019
An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body
Hongyi Li, Chongqing Yang, Yajun Yin, Fang Wang, Min Chen, Liang Xu, Naili Wang, Di Zhang, Xiaoxia Wang, Yiya Kong, Qin…Researchers investigated a potential fluid transport system within the body's fibrous connective tissues, separate from blood and lymphatic vessels. Using fluorescent tracers in cadavers and MRI in volunteers, they visu…
interstitial fluidinterstitiuminterstitial spacesfascia fluid - A+++2019
Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body
Hongyi Li, Yajun Yin, Chongqing Yang, Min Chen, Fang Wang, Chao Ma, Hua Li, Yiya Kong, Fusui Ji, Jun HuInterstitial fluid, the fluid in the spaces between our cells, has long been thought to move only over short distances. This study proposes a different view, suggesting that a network of fibrous connective tissues acts…
interstitial fluidinterstitiuminterstitial spacesfascia fluid - A+++2019
Tentorium Cerebelli: Muscles, Ligaments, and Dura Mater, Part 1
Bruno Bordoni, Marta Simonelli, Maria Marcella LaganaIn this narrative review, the authors describe the anatomy of the tentorium cerebelli, part of the reciprocal tension membranes that divide areas of the brain. They highlight its connections to the dura mater, ligaments…
fasciafascial systemdura matercraniotentorium cerebelli - A+++2019
Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience
Patrick J McCullough, Douglas S Lehrer, Je!rey AmendThis observational study followed long-term hospitalized patients over seven years to evaluate the safety of high daily doses of vitamin D3. Patients received supplements ranging from 5,000 to 50,000 international units…
vitamin DIntact parathyroid hormoneLong-term supplementationAdverse events - A+++2019
Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials
Mikee Liugan, Anitra C CarrThis systematic review examined how vitamin C supplementation affects neutrophils, a key type of immune cell. Researchers analyzed 16 randomized controlled trials that measured neutrophil functions like their ability to…
vitamin C; ascorbic acid; neutrophils; polymorphonuclear leukocytes; migration; chemotaxis; apoptosis; phagocytosis; oxidative burst; systematic review - A+++2019
Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury
Enrico Sangiovanni, Marco Fumagalli, Barbara Pacchetti, Stefano Piazza, Andrea Magnavacca, Saba Khalilpour, Gloria Melz…This in vitro study investigated how Cannabis sativa extract and its component cannabidiol (CBD) affect inflammation in human skin cells. Researchers found that both the extract and pure CBD reduced the release of sever…
Cannabis sativa L.; cannabidiol; fibroblasts; keratinocytes; skin inflammation; wound injury. - A+++2019
Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study
Toshio Mikami, Kohei Tano, Hosung Lee, Hyowon Lee, Jonghyuk Park, Fumiaki Ohta, Tyler W LeBaron, Shigeo OhtaThis randomized, double-blind, placebo-controlled study investigated the effects of drinking hydrogen-infused water (H2 water) before exercise. Across two experiments involving both untrained and trained participants on…
exercise; fatigue; hydrogen; hydrogen water - A+++2019
Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans
Joey S J Smeets, Astrid M H Horstman, Georges F Vles, Pieter J Emans, Joy P B Goessens, Annemie P Gijsen, Janneau M X v…This study measured protein synthesis rates directly in various human knee joint tissues for the first time. Researchers collected samples from muscle, tendon, ligaments, cartilage, and bone during total knee replacemen…
nutritiontissue protein synthesis rateamino acid content in tissues