Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19
Mithila Farjana, Akhi Moni, Abdullah Al Mamun Sohag, Adeba Hasan, Abdul Hannan, Golzar Hossain, Jamal UddinThis narrative review explores the potential of Vitamin C (L-ascorbic acid) for managing complications associated with COVID-19. The authors highlight its known functions, including antioxidant, anti-inflammatory, and i…
COVID-19; SARS-CoV-2; Vitamin C; Immune response; In!ammation - A+++2020
Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis randomized controlled trial investigated how daily resveratrol supplementation affects brain health in postmenopausal women over a 12-month period. Participants took either 75 mg of trans-resveratrol twice daily or…
ageing; cerebrovascular function; cognitive decline; menopause; neurovascular coupling; nutraceutical; phytoestrogen; resveratrol - A+++2020
The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1
Bruno Bordoni, Stevan Walkowski, Bruno Ducoux, Filippo TobbiIn this review article, the first of a two-part series, the authors examine the foundational assumptions of cranial osteopathy. They argue that a theoretical model must evolve with new scientific information to avoid be…
fasciaOsteopathicdiaphragmcraniocraniosacral - A+++2020
Manipulation of the Fascial System Applied During Acute Inflammation of the Connective Tissue of the Thoracolumbar Region Affects Transforming Growth Factor-β1 and Interleukin-4 Levels: Experimental Study in Mice
Maria Elisa Duarte França, Larissa Sinhorim, Daniel Fernandes Martins, Robert Schleip, Nicolas A M M Machado-Pereira, G…This animal study investigated the effects of manual fascial manipulation on acute inflammation in the connective tissue of mice's lower backs. Researchers induced inflammation and then applied a specific manipulation p…
inflammationcytokinesfascial systemManipulationmice - A+++2020
A Review of the Theoretical Fascial Models: Biotensegrity, Fascintegrity, and Myofascial Chains
Bruno Bordoni, Tom MyersIn this review article, the authors discuss three theoretical models used to understand how fascia functions in the body. The biotensegrity model is mechanical and considers the solid fascia, while the fascintegrity mod…
fasciaMyofascialOsteopathicphysiotherapymyofascial chains - A+++2020
Ascorbate as Prophylaxis and Therapy for COVID-19—Update From Shanghai and U.S. Medical Institutions
Richard Z Cheng, Mikhail Kogan, Devra DavisThis 2020 report describes how a medical panel in Shanghai evaluated the use of intravenous (IV) ascorbate, or vitamin C, for patients with severe COVID-19. The panel reviewed existing studies and preliminary data from…
COVID-19public healthglobal healthintravenous ascorbate - A+++2019
Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts
Thivanka Muthumalage, Irfan RahmanThis laboratory study investigated how cannabidiol (CBD) influences inflammatory responses in lung epithelial cells, fibroblasts, and immune cells. The researchers found that CBD can reduce inflammation triggered by ext…
CBD; E-cigarette; E-liquid; Lung; Marijuana; Vaping - A+++2019
Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience
Patrick J McCullough, Douglas S Lehrer, Je!rey AmendThis observational study followed long-term hospitalized patients over seven years to evaluate the safety of high daily doses of vitamin D3. Patients received supplements ranging from 5,000 to 50,000 international units…
vitamin DIntact parathyroid hormoneLong-term supplementationAdverse events - A+++2019
Tentorium Cerebelli: the Bridge Between the Central and Peripheral Nervous System, Part 2
Bruno Bordoni, Marta Simonelli, Maria Marcella LaganaThis article, the second in a series, describes the tentorium cerebelli—a meningeal structure related to the skull, nervous system, and cervical spine. The authors discuss its complex relationships, including its neurol…
fasciapaincraniotentorium cerebellivenous circulation - A+++2019
The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma
Francesca Rossi, Chiara Tortora, Francesca Punzo, Giulia Bellini, Maura Argenziano, Alessandra Di Paola, Marco Torella,…Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) system's receptors are the cannabinoid receptor…
CB1; CB2; TRPV1; bone; osteoblasts; osteoclasts; osteoporosis; osteosarcoma - A+++2019
New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System
Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C KonjeThis study investigated the role of the endocannabinoid system in the development of uterine leiomyomas, commonly known as fibroids. Researchers analyzed tissue samples and found that the expression of specific receptor…
CannabinoidsCannabinoid receptorsuterine myomfibroids - A+++2019
Is It All About the Fascia? A Systematic Review and Meta-analysis of the Prevalence of Extramuscular Connective Tissue Lesions in Muscle Strain Injury
Jan Wilke, Luiz Hespanhol, Martin BehrensThis systematic review and meta-analysis examined how often connective tissue is damaged in athletic muscle strains. Researchers analyzed 16 imaging studies and found that lesions to the fascia and tendons are highly pr…
return to play; muscle injury; collagen; imaging; ultrasound; MRI