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Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?

Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Aïchata Niang, Manuel Dauchez, Nicolas Belloy, François-Xavier Maquart, Stéphanie Baud, Stéphane Brézillon
fibromodulinSLRPsLumicanDecorinBiglycanMMP-14Structure and molecular modelingGlycosylation
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Key takeaways
  1. 01SLRPs are proteins that help regulate the extracellular matrix
  2. 02Some SLRPs can inhibit cancer progression
  3. 03They may work by deactivating matrix-degrading enzymes (MMPs)
  4. 04The SLRP lumican directly inhibits the enzyme MMP-14

A family of matrix proteins called SLRPs may help inhibit cancer progression by interacting with and deactivating specific enzymes.

Abstract

Small leucine-rich proteoglycans (SLRPs) are important regulators of extracellular matrix assembly and cell signaling. They are a family of proteoglycans that are present in extracellular matrix and that share in common multiple repeats of a leucine-rich structural motif. SLRPs have been identified as inhibitors of cancer progression by affecting MMPs, especially MMP-14 activity. Lumican, a member of the SLRPs family, and its derived peptides were shown to possess anti-tumor activity. Interestingly, it was demonstrated recently that lumican interacts directly with the catalytic domain of MMP-14 and inhibits its activity. The aim of this review was to summarize the interactions between SLRPs and MMPs with a special interest to lumican.

Cite this study
APA
Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Aïchata Niang, Manuel Dauchez, Nicolas Belloy, François-Xavier Maquart, Stéphanie Baud, & Stéphane Brézillon (2018). Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?. https://fasciaresearchdatabase.com/small-leucine-rich-proteoglycans-and-matrix-metalloproteinase-14-key-partners/
MLA
Katarzyna Pietraszek-Gremplewicz, et al. "Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?." 2018, https://fasciaresearchdatabase.com/small-leucine-rich-proteoglycans-and-matrix-metalloproteinase-14-key-partners/.
Chicago
Katarzyna Pietraszek-Gremplewicz et al. 2018. "Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?.". https://fasciaresearchdatabase.com/small-leucine-rich-proteoglycans-and-matrix-metalloproteinase-14-key-partners/