TGF-β: Guardian of T Cell Function
Soyoung A Oh, Ming O Li
Key takeaways
- 01This review discusses TGF-β's role in T cell function
- 02TGF-β regulates T cell development, homeostasis, and tolerance
- 03Helps maintain a diverse and self-tolerant T cell pool
- 04Its regulatory mechanisms and signaling pathways are complex
The cytokine TGF-β is a master regulator of T cells, which are essential components of the adaptive immune system.
Abstract
A fundamental aspect of the adaptive immune system is the generation and maintenance of a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development, homeostasis, tolerance, and differentiation, the highly evolutionarily conserved cytokine TGF-β critically supports a functional T cell pool. The pleiotropic nature of this regulation is likely due to the elaborate control of TGF-β production and activation in the immune system, and the intricacy of TGF-β signaling pathways. In this review we discuss the current understanding of TGF-β regulation of T cells.
Cite this study
- APA
- Soyoung A Oh, & Ming O Li (2013). TGF-β: Guardian of T Cell Function. https://fasciaresearchdatabase.com/tgf-%ce%b2-guardian-of-t-cell-function/
- MLA
- Soyoung A Oh, and Ming O Li. "TGF-β: Guardian of T Cell Function." 2013, https://fasciaresearchdatabase.com/tgf-%ce%b2-guardian-of-t-cell-function/.
- Chicago
- Soyoung A Oh, Ming O Li. 2013. "TGF-β: Guardian of T Cell Function.". https://fasciaresearchdatabase.com/tgf-%ce%b2-guardian-of-t-cell-function/