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Glycosaminoglycans och proteoglycans i palmar fascia hos patienter med Dupuytrens sjukdom

Priscilla Carneiro Hirai Nascimento, Elsa Yoko Kobayashi, Luiz Guilherme de Saboya Lenzi, João baptista Gomes dos Santos, Helena Bonciani Nader, Flávio Faloppa
FasciaProteoglykanerDupuytren contractureGlykosaminoglykaner
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Nyckelinsikter
  1. 01Undersökte glykosaminoglykaner (GAG) i vävnad från Dupuytrens kontraktur
  2. 02Analyserade prover från palmarfascian hos 23 patienter
  3. 03Fann en signifikant ökning av GAG jämfört med kontrollvävnad
  4. 04Tyder på att GAG kan spela en roll i sjukdomsprocessen

Vävnad som påverkats av Dupuytrens kontraktur innehåller signifikant högre nivåer av glykosaminoglykaner, en viktig komponent i bindväv.

Abstract

Objective: : To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD).

Methods: : This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or McCash were evaluated by electrophoresis for identification of GAGs. The quantification was carried out by immunofluorescence and dosage of proteins for different types of glycosaminoglycans. The results were expressed in percentage and statistically evaluated.

Results: : A significant increase was observed through eletrophoresis in GAGs, as compared to the control (p<0.05). Immunofluorescence of hyaluronic acid was reduced (23 times) when compared to the control (p<0.0001).

Conclusion: : An increase of sulfated GAGs in Dupuytren's disease, mainly dermatan sulfate, was evident from our results, as well as a pronounced decrease of hyaluronic acid in the palmar aponeurosis from the same patients. Level of Evidence III, Case-Control Study.

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APA
Priscilla Carneiro Hirai Nascimento, Elsa Yoko Kobayashi, Luiz Guilherme de Saboya Lenzi, João baptista Gomes dos Santos, Helena Bonciani Nader, & Flávio Faloppa (2015). Glycosaminoglycans och proteoglycans i palmar fascia hos patienter med Dupuytrens sjukdom. https://fasciaresearchdatabase.com/glycosaminoglycans-and-proteoglycans-in-palmar-fascia-of-patients-with-dupuytren/
MLA
Priscilla Carneiro Hirai Nascimento, et al. "Glycosaminoglycans och proteoglycans i palmar fascia hos patienter med Dupuytrens sjukdom." 2015, https://fasciaresearchdatabase.com/glycosaminoglycans-and-proteoglycans-in-palmar-fascia-of-patients-with-dupuytren/.
Chicago
Priscilla Carneiro Hirai Nascimento et al. 2015. "Glycosaminoglycans och proteoglycans i palmar fascia hos patienter med Dupuytrens sjukdom.". https://fasciaresearchdatabase.com/glycosaminoglycans-and-proteoglycans-in-palmar-fascia-of-patients-with-dupuytren/
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