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Effekter av växtsteroler från Aloe vera-gel på humana dermala fibroblaster in vitro och på hudens tillstånd hos japanska kvinnor

Miyuki Tanaka, Eriko Misawa, Koji Yamauchi, Fumiaki Abe, Chiaki Ishizaki
Oral supplementeringaloe sterol; collagen; rynka
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Nyckelinsikter
  1. 01Aloe-steroler stimulerar hudens fibroblaster att producera mer kollagen och hyaluronsyra
  2. 02Dagligt intag av Aloe vera-gelpulver minskade rynkdjupet hos kvinnor över 40 år
  3. 03Studien visade en ökning av hudens fukthalt efter åtta veckors användning
  4. 04Deltagare som tog Aloe-tillskott uppvisade även en minskning i kroppsfettprocent
  5. 05Inga biverkningar rapporterades vid det dagliga intaget av Aloe-steroler

Dagligt intag av Aloe vera-steroler kan minska rynkor och öka hudens fukt genom att stimulera produktionen av kollagen och hyaluronsyra.

Abstract

Background: Aloe is known for its topical use for treating wounds and burns. Many previous studies reported the healing effects of Aloe vera. However, there are few clinical studies on the effect of orally administered A. vera gel on the skin. Aloe sterols are a type of plant sterols that have the capability to regulate the metabolism of glucose and lipids. In a recent study, we confirmed that ingested Aloe sterols reached the peripheral tissues through the bloodstream. However, their influence on dermal fibroblasts has not been investigated.

Methods: First, we investigated the capability of Aloe sterols (cycloartenol and lophenol) to stimulate human dermal fibroblasts in vitro. Then, we investigated the effect of intake of Aloe vera gel powder (AVGP) containing 40 μg Aloe sterols on the skin conditions in Japanese women with dry skin in a randomized, double-blind, placebo-controlled trial.

Results: After cocultivation with Aloe sterols, the production of collagen and hyaluronic acid increased by approximately two-fold and 1.5-fold, and gene expression levels of these enzymes responsible for their synthesis were also observed in human dermal fibroblasts. An increase in arm skin hydration was observed at 8 weeks in the AVGP group, whereas a slight decrease in arm skin hydration was noted in the placebo group. However, there was no statistical difference between AVGP and placebo groups in skin moisture. In subgroup analysis, the change in the mean wrinkle depth was significantly lower in the AVGP group than in the control group. In addition, percent body fat after 8 weeks was significantly lower in the AVGP group. No AVGP intake-dependent harmful phenomenon was observed during the intake period.

Conclusion: The present study confirms that daily oral Aloe sterol-containing AVGP significantly reduced facial wrinkles in women aged ≥40 years, and Aloe sterols stimulate collagen and hyaluronic acid production by human dermal fibroblasts.

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APA
Miyuki Tanaka, Eriko Misawa, Koji Yamauchi, Fumiaki Abe, & Chiaki Ishizaki (2015). Effekter av växtsteroler från Aloe vera-gel på humana dermala fibroblaster in vitro och på hudens tillstånd hos japanska kvinnor. https://fasciaresearchdatabase.com/effects-of-plant-sterols-derived-from-aloe-vera-gel-on-human-dermal-fibroblasts-in-vitro-and-on-skin-condition-in-japanese-women/
MLA
Miyuki Tanaka, et al. "Effekter av växtsteroler från Aloe vera-gel på humana dermala fibroblaster in vitro och på hudens tillstånd hos japanska kvinnor." 2015, https://fasciaresearchdatabase.com/effects-of-plant-sterols-derived-from-aloe-vera-gel-on-human-dermal-fibroblasts-in-vitro-and-on-skin-condition-in-japanese-women/.
Chicago
Miyuki Tanaka et al. 2015. "Effekter av växtsteroler från Aloe vera-gel på humana dermala fibroblaster in vitro och på hudens tillstånd hos japanska kvinnor.". https://fasciaresearchdatabase.com/effects-of-plant-sterols-derived-from-aloe-vera-gel-on-human-dermal-fibroblasts-in-vitro-and-on-skin-condition-in-japanese-women/
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