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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1,105–1,116 of 1,127 studies · page 93/94With summary
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  1. A
    1999

    Tensegrity and mechanoregulation: from skeleton to cytoskeleton

    Christopher S Chen, Donald E Ingber

    This review article explores how mechanical forces are transmitted from the whole body down to individual cells. The authors propose that a design principle called "tensegrity," which uses continuous tension and local c…

    extracellular matrixTensegritycytoskeletonmechanotransductionIntegrins
  2. A
    1999

    Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL)

    Steffen Oesser, Milan Adam, Wilfried Babel, Jürgen Seifert

    In this animal study, researchers investigated how gelatin hydrolysate is absorbed and distributed in the bodies of mice. Using a radioactive label, they tracked the gelatin after it was administered orally. The results…

    gelatin hydrolysate; peptide absorption; organ distribution; cartilage; mice (C57/BL)
  3. A+++
    1998

    The Architecture of Life

    Donald E Ingber

    As this is a title-only entry, the full text has not yet been reviewed. The title, "The Architecture of Life," suggests a focus on the structural principles governing biological systems, possibly involving concepts like…

    Tensegritycytoskeleton
  4. C
    1998

    Thyroid hormone-induced upregulation of Na channels and Na-K pumps: implications for contractility

    Adrian P Harrison, T Clausen

    In this animal study, researchers investigated how thyroid hormone affects muscle endurance in rats. They treated rats with the hormone T3, which increased the concentration of both sodium (Na+) channels and sodium-pota…

    NaKThyroid hormone
  5. A
    1997

    Tensegrity: The Architectural Basis of Cellular Mechanotransduction

    D E Ingber

    This 1997 review article proposes a model for how cells sense and respond to physical forces, a process called mechanotransduction. The author suggests that cells are built using 'tensegrity' architecture, a system of b…

    extracellular matrixsignal transductioncytoskeletonIntegrinsmechanoreceptor
  6. C
    1997

    Biophoton emission of the human body

    S Cohen, F A Popp

    Researchers measured "ultraweak" photon emissions, or biophotons, from the human body using a sensitive light detector. The study, involving about 200 individuals, found that these emissions are not random. They appear…

    BiophotonBiological regulationBiological rhythmsHuman body measurmentLeft right symmetry
  7. A++
    1997

    Functional morphology of serially linked skeletal muscle fibers

    T Hijikata, H Ishikawa

    Skeletal muscle fibers don't always run the full length of a muscle; they often link together in series. This study describes two main ways these connections occur: end-to-end via connective tissue plates, or by overlap…

    EndomysiumMuscle fiber morphologyLinked muscle fiber
  8. A+
    1997

    Mechanical Loading and TGF-b Regulate Proteoglycan Synthesis in Tendon

    James R Robbins, Stephen P Evanko, Kathryn G Vogel

    Tendons can develop cartilage-like properties in areas subjected to compressive loading. In this study on fetal bovine tendon tissue, researchers investigated how mechanical compression affects the cells. They found tha…

    load forcetissue transition
  9. A
    1996

    Effects of continuous and Intermittent forces on human fibroblasts in vitro

    Aldo Carano, Giuseppe Siciliani

    This in vitro study investigated how human connective tissue cells (fibroblasts) respond to different types of mechanical force. Researchers grew fibroblasts on flexible membranes and subjected them to either continuous…

    fibroblasttissue remodelingmechanical load
  10. B
    1996

    Selective regulation of myofiber differentiation by energy status during postnatal development

    Adrian P Harrison, A M Rowlerson, M J Dauncey

    In this animal study, researchers investigated how energy intake and environmental temperature affect muscle development in young pigs. The pigs were divided into groups that received either a high or low energy intake…

    skeletal muscledifferentiationmyosin isoformsnutritiontemperature
  11. A++
    1996

    Clinical consequences of anal sphincter rupture during vaginal delivery

    E K Fornell, G Berg, O Hallböök, L S Matthiesen, R Sjödahl

    This study investigated the incidence and consequences of anal sphincter tears during childbirth. Researchers followed 51 women with a diagnosed tear and 31 women without one for six months after delivery. They found th…

    anal sphincter injury; incontinence; anal pressure
  12. A
    1994

    Glutathione-Ascorbic Acid Antioxidant System in Animals

    Alton Meister

    This 1994 publication by Alton Meister discusses the biochemical interaction between glutathione and ascorbic acid (Vitamin C) within animal antioxidant systems. As the source material is limited to the title, the summa…

    Vitamin CAscorbic acidantioxidantanimals