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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1,093–1,104 of 1,127 studies · page 92/94With summary
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  1. A
    2002

    Detection of changes in cartilage water content using MRI T2-mapping in vivo

    C Liess, S Lüsse, N Karger, M Heller, C-C Glüer

    Early-stage osteoarthritis (OA) is characterized by an elevated water content in cartilage. This study investigated if a specific MRI technique, T2-mapping, could detect these changes in living subjects. Healthy volunte…

    MRIEarly osteoarthritisWater contentT2-mapping
  2. B
    2002

    Mammalian Hyaluronan Synthases

    Naoki Itano, Koji Kimata

    This 2002 review article describes the three enzymes that produce hyaluronan (HA) in mammals: HAS1, HAS2, and HAS3. These three enzyme isoforms have different characteristics and create different sizes of HA molecules.…

    hyaluronanBiosynthesisglycosyltransferasesynthasesHAS isoforms
  3. B
    2002

    Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

    Christian Termeer, Frauke Benedix, Jonathon Sleeman, Christina Fieber, Ursula Voith, Thomas Ahrens, Kensuke Miyake, Mar…

    During inflammation, components of our connective tissue like hyaluronic acid (HA) can break down. This study investigated how small fragments of HA affect the immune system. Researchers found that these fragments activ…

    hyaluronanextracellular matrixtoll-like receptorsglycosaminoglycansdendritic cells
  4. A
    2002

    Evidence of Connective Tissue Involvement in Acupuncture

    Helene M Langevin, David L Churchill, Junru Wu, Gary J Badger, Jason A Yandow, James R Fox, Martin H Krag

    Researchers investigated the "needle grasp" phenomenon in acupuncture, where it becomes harder to pull a needle out after manipulation. They hypothesized this is caused by connective tissue winding around the needle, ra…

    mechanical stressSubcutaneous tissueultrasound.Biomechanicshistology
  5. A++
    2002

    Effects of Biomechanical Stress on Bones in Animals

    D B Burr, A G Robling, C H Turner

    This animal study investigated how bones adapt to mechanical stress. The researchers found that cyclic loading, like in exercise, creates fluid flow within the bone that signals it to adapt. The rate of this loading is…

    Exercise; Mechanotransduction; Sensitivity; Saturation; Adaptation
  6. 1A+
    2001

    Hyaluronan and its catabolic products in tissue injury and repair

    P W Noble

    This narrative review explores the role of hyaluronan (HA), a common component of connective tissue, in the body's response to injury. In healthy tissues, HA exists as a large molecule that helps maintain structural int…

    hyaluronaninflammationCD44respons to injury
  7. A
    2001

    Hyaluronan and Homeostasis: A Balancing Act

    M I Tammi, A J Day, E A Turley

    As only the title of this paper is available, it has not yet been summarized. The title suggests the article discusses the role of hyaluronan in maintaining homeostasis, the body's state of physiological balance. This i…

    hyaluronan homeostasis
  8. C
    2001

    Collagen accumulation in muscles of children with cerebral palsy and correlation with severity of spasticity

    Booth, Cortina-Borja, Theologis

    This study investigated the link between connective tissue and muscle function in children with cerebral palsy (CP). Researchers analyzed muscle samples from 26 children, comparing collagen content to clinical measures…

    Cerebral palsycollagenspasticity
  9. A
    2001

    Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture

    Helene M Langevin, David L Churchill, Marilyn J Cipolla

    This paper proposes a hypothesis for how acupuncture might work. The authors focus on the "de qi" sensation, which includes the acupuncturist feeling a "needle grasp" in the tissue. They suggest that when an acupuncture…

    collagenmechanotransductionmeridian
  10. A
    2000

    Adhesive Capsulitis

    Jo A Hannafin, Theresa A Chiaia

    In this 2000 review article, the authors examine adhesive capsulitis, or frozen shoulder, a condition of unknown cause that restricts shoulder motion. They review what is known about its etiology and critically evaluate…

    frozen shoulderAdhesive capsulitisstages
  11. A+
    2000

    Role of collagen hydrolysate in bone and joint disease

    R W Moskowitz

    This narrative review examines the role of collagen hydrolysate in the management of osteoarthritis and osteoporosis. Research suggests that a daily intake of 10 grams of pharmaceutical-grade collagen hydrolysate may he…

    supplementationOsteoporosishydrolysate collagenosteartrithis
  12. A
    2000

    Effect of Mechanical Load on Articular Cartilage Collagen Structure: A Scanning Electron-Microscopic Study

    Max J Kääb, Keita Ito, Berton Rahn, John M Clark, Hubert P Nötzli

    This study on rabbit knees examined how static mechanical loads affect the collagen structure of articular cartilage. Researchers applied varying levels of force for different durations to simulate muscle activity, then…

    rabbit.Morphology; Loadingmechanical; Collagen fibers; Scanning electron microscopy; Cryofixation; Freeze substitution