Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesAnti-angiogenic effect of high doses of ascorbic acid
This laboratory study investigated how high doses of ascorbic acid (vitamin C) affect the formation of new blood vessels, a process called angiogenesis. Researchers exposed several types of human endothelial cells, incl…
Fibronectin Unfolding Revisited: Modeling Cell Traction- Mediated Unfolding of the Tenth Type-III Repeat
Cells build the extracellular matrix by pulling on the protein fibronectin, causing it to assemble into fibrils. This study used computer simulations to investigate how this process works at a molecular level. Researche…
Differential effects of hyaluronan and its fragments on fibroblasts: Relation to wound healing
This lab study investigated how hyaluronan (HA) of different molecular sizes affects human fibroblast cells, which are key to wound healing. Researchers exposed fibroblasts to native HA and two smaller fragments. All th…
Hyaluronan (HA) Deposition Precedes and Promotes Leukocyte Recruitment in Intestinal Inflammation
Hyaluronan (HA) accumulation is common in inflammatory bowel disease (IBD), but whether it is a cause or an effect has been unclear. In this study using a mouse model and human tissue, researchers found that HA builds u…
Simple geometry in complex organisms
This theoretical paper explores how simple geometric principles can explain the formation of complex biological structures. The author revisits ancient ideas about fundamental shapes, connecting them to modern concepts…
Vitamin C Deficiency in a University Teaching Hospital
This study investigated vitamin C levels in patients at a Canadian teaching hospital. Researchers found that 60% of patients had low levels and 19% were deficient, a much higher rate than in a healthy reference group. F…
Correlation Between Fluctuations in Human Ultra-weak Photon Emission and EEG Alpha Rhythm
This study investigated the relationship between ultra-weak photon emission (UPE) from the skin and brain activity measured via EEG. Researchers recorded light emission from the hand while simultaneously monitoring brai…
Dorsal horn neurons having input from low back structures in rats
In this animal study, researchers in rats investigated how spinal cord nerve cells (dorsal horn neurons) process signals from the low back. They found that these neurons often receive input from several different tissue…
Expression of the endocannabinoid system in fibroblasts and myofascial tissues
This narrative review investigates the endocannabinoid (eCB) system, a network in the body similar to the endorphin system that helps regulate pain and inflammation. Using a bioinformatics approach to analyze existing d…
Tensegrity and Mechanotransduction
This article summarizes a lecture on how mechanical forces influence biological processes at the cellular level. The author describes mechanotransduction, the process by which cells convert physical forces into biochemi…
Diagnosis and management of adhesive capsulitis
This 2008 review discusses adhesive capsulitis, also known as frozen shoulder, a disabling musculoskeletal condition. The authors cover the diagnosis and management of the condition, which can cause significant morbidit…
Tensegrity-Based Mechanosensing from Macro to Micro
This review article, based on a lecture, explores how cells convert mechanical signals into biochemical responses. The author proposes that the body uses "tensegrity" (tensional integrity) principles, where interconnect…