Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2011
Sensory Innervation of the Nonspecialized Connective Tissues in the Low Back of the Rat
Sarah M Corey, Margaret A Vizzard, Gary J Badger, Helene M LangevinIn this animal study, researchers investigated the sensory nerves in the nonspecialized connective tissue of the rat low back, an area where knowledge is limited. Using 3D reconstruction and dye-labeling techniques, the…
fasciaConnective tissueinnervationlow back painmusculoskeletal pain - A2011
ExtracellularMatrix Degradation and Remodeling in Development and Disease
Pengfei Lu, Ken Takai, Valerie M Weaver, Zena WerbIn this review, the authors describe the extracellular matrix (ECM) as a dynamic structure that is constantly being remodeled. This process of breakdown and rebuilding is essential for normal bodily functions like tissu…
fasciaextracellular matrixmatrix remodeling - B2011
The effect of molecular weight on hyaluronan’s cartilage boundary lubricating ability e alone and in combination with proteoglycan 4
J J Kwiecinski, S G Dorosz, T E Ludwig, S Abubacker, Mary K Cowman, T A SchmidtThis study investigated the lubricating ability of hyaluronan (HA) in articular cartilage, focusing on how its molecular weight affects function. Researchers found that higher molecular weight hyaluronan was more effect…
hyaluronanCartilage boundary lubricationProteoglycan 4 (PRG4) - A+2011
The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health
Gerry K SchwalfenbergThis 2011 review examined the published medical literature to evaluate the health benefits of an alkaline diet. The author looked at studies on the body's pH and its connection to bone health, muscle function, back pain…
Metabolic acidosisalkaline dietmetabolic syndrom - A+2011
Diet-induced metabolic acidosis
María M Adeva, Gema SoutoThe typical Western diet, high in animal products and low in fruits and vegetables, can lead to a state of chronic, low-grade metabolic acidosis. This means the body becomes slightly more acidic, a situation that can wo…
Metabolic acidosisAmmonium ionsCitrateInsulin resistance - B2011
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44
Yuejuan Li, Dianhua Jiang, Jiurong Liang, Eric B Meltzer, Alice Gray, Riu Miura, Lise Wogensen, Yu Yamaguchi, Paul W No…This study investigated the mechanisms behind severe lung fibrosis, a condition where excessive connective tissue builds up in the lungs. Using a mouse model, researchers found that fibroblasts, a type of connective tis…
hyaluronanCD44fibrosis - A2011
Fascia and the mechanism of acupuncture
Steven Finando, Donna FinandoThis theoretical paper re-evaluates the mechanisms of acupuncture. The authors propose that fascia, the body's connective tissue network, is the structure that explains how acupuncture works. They argue for this model b…
fasciaacupunctureShamPlaceboMechanism - A2011
Correlations Between Fasciology and Yin Yang Doctrine
Hui Tao, Mei-Chun Yu, Hui-Ying Yang, Rong-Mei Qu, Chun Yang, Xin Zhou, Yu Bai, Jing-Peng Wu, Jun Wang, Ou Sha, Lin YuanThis theoretical paper explores correlations between "fasciology," a model based on 3D reconstruction of connective tissue, and the traditional Chinese doctrine of yin and yang. According to fasciology, the body can be…
fasciafasciologyfascial anatomytwo-system theoryyin yang doctrine - B2011
Fascia redefined: anatomical features and technical relevance in fascial flap surgery
Carla Stecco, Cesare Tiengo, Antonio Stecco, Andrea Porzionato, Veronica Macchi, Robert Stern, Raffaele De CaroFascia has traditionally been seen as a passive wrapping, but this review redefines it as a dynamic tissue with its own complex blood supply and innervation. The authors detail the specific characteristics of different…
hyaluronanfasciaConnective tissueaponeurosisFlaps - A2011
Pandiculation: Nature’s way of maintaining the functional integrity of the myofascial system?
Luiz Fernando BertolucciThis paper explores the hypothesis that pandiculation—the involuntary stretching and yawning most animals do upon waking—serves a key role for the locomotor system. Beyond preparing the nervous system for wakefulness, t…
fasciaConnective tissuemyofasciayawningsleep-wake rhythm - A2011
Fibroblast cytoskeletal remodeling contributes to connective tissue tension
H M Langevin, N A Bouffard, J R Fox, B M Palmer, J Wu, J C Iatridis, W D Barnes, G J Badger, A K HoweThe mechanical properties of connective tissue, such as its elasticity and resistance, have traditionally been attributed to its non-cellular matrix. This study investigated the role of fibroblasts, the cells residing w…
fasciaConnective tissuefibroblastcytoskeletal remodeling - A+2011
Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial
T E McAlindon, M Nuite, N Krishnan, R Ruthazer, L L Price, D Burstein, J Grif!th, K FlechsenharThis pilot randomized controlled trial investigated if collagen hydrolysate supplements could affect knee cartilage in people with mild osteoarthritis. Using a specialized MRI technique (dGEMRIC), researchers tracked ch…
MRIosteoarthritisMagnetic resonance imagingCartilageDelayed gadolinium enhanced