Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesINTERSTITIAL FLUID AND LYMPH FORMATION AND TRANSPORT: PHYSIOLOGICAL REGULATION AND ROLES IN INFLAMMATION AND CANCER
This 2012 review explores the interstitium, the fluid-filled space surrounding our cells that contains interstitial fluid (IF). Formed by filtration from blood capillaries and cleared by lymphatic vessels, IF and its fl…
Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes
This study on mouse cartilage cells investigated how different sizes of hyaluronan (HA) affect inflammation. Researchers found that small HA fragments increased the production of several inflammatory markers. In contras…
Fascia Research from a Clinician/Scientist’s Perspective
In this perspective piece, a clinician-scientist summarizes exciting areas in fascia research. The article describes the fascial network as a body-wide system that connects individual cells and shares loads with muscles…
The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health
This 2011 review examined the published medical literature to evaluate the health benefits of an alkaline diet. The author looked at studies on the body's pH and its connection to bone health, muscle function, back pain…
Elevated [11C]-D-Deprenyl Uptake in Chronic Whiplash Associated Disorder Suggests Persistent Musculoskeletal Inflammation
Diagnosing chronic whiplash-associated disorder (WAD) is often difficult, as standard structural imaging methods seldom show clear signs of injury. This study used Positron Emission Tomography (PET) with a tracer molecu…
Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial
This pilot randomized controlled trial investigated if collagen hydrolysate supplements could affect knee cartilage in people with mild osteoarthritis. Using a specialized MRI technique (dGEMRIC), researchers tracked ch…
Sensory Innervation of the Nonspecialized Connective Tissues in the Low Back of the Rat
In this animal study, researchers investigated the sensory nerves in the nonspecialized connective tissue of the rat low back, an area where knowledge is limited. Using 3D reconstruction and dye-labeling techniques, the…
Fibroblasts and Myofibroblasts: What are we talking about?
This 2011 narrative review explores the roles of fibroblasts and myofibroblasts, two key cell types in the heart's connective tissue. Once considered static, research indicates these cells are dynamic and play an active…
Why does chronic inflammation persist: An unexpected role for fibroblasts
This 2011 review explores why chronic inflammation persists. Traditionally, research has focused on immune cells, but this text highlights the crucial role that stromal cells, particularly fibroblasts, play in sustainin…
The Genetics of Vitamin C Loss in Vertebrates
This narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…
ExtracellularMatrix Degradation and Remodeling in Development and Disease
In this review, the authors describe the extracellular matrix (ECM) as a dynamic structure that is constantly being remodeled. This process of breakdown and rebuilding is essential for normal bodily functions like tissu…
Management of the stiff shoulder. A prospective multicenter comparative study of the six main techniques in use: 235 cases
This prospective study compared six different therapeutic techniques for stiff shoulder in 235 patients. Researchers evaluated conventional rehabilitation below the pain threshold against self-rehabilitation pushing pas…