Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesThe thoracolumbar fascia: anatomy, function and clinical considerations
This overview paper examines the anatomy and function of the thoracolumbar fascia (TLF), the complex sheet of connective tissue in the lower back. The authors describe its multiple layers, which separate and connect the…
Primo Vascular System as a New Morphofunctional Integrated System
This narrative review summarizes research on the primo vascular system (PVS), a proposed anatomical network found throughout the body. The authors describe the methods and instruments used to study this system, primaril…
Stretching of the Back Improves Gait, Mechanical Sensitivity and Connective Tissue Inflammation in a Rodent Model
In this rodent study, researchers investigated how stretching affects inflammation in the connective tissue of the low back. They first induced local inflammation, which resulted in altered gait, increased mechanical se…
An MRI Study of Symptomatic Adhesive Capsulitis
This study used magnetic resonance imaging (MRI) to compare the shoulders of 60 patients with clinically diagnosed adhesive capsulitis (frozen shoulder) to 60 healthy control subjects. Researchers found significant diff…
Hyaluronic acid, A key molecule in skin aging
This review article discusses the role of hyaluronic acid (HA) in skin aging. The authors explain that youthful skin's plumpness and resilience are largely due to its high water content, which HA is uniquely able to ret…
Myoton Pro: A Novel Tool for the Assessment of Mechanical Properties of Fascial Tissues
This research entry, for which only the title is available, appears to introduce a device called the MyotonPRO. The title suggests its purpose is to assess the mechanical properties of fascial tissues, such as their sti…
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis
Fibrosis is a process of excessive connective tissue formation, leading to scarring and stiffness in organs. A protein called Connective Tissue Growth Factor (CTGF) plays a central role in driving this process. This res…
The role of stromal cells in the persistence of chronic inflammation
This review article explores why chronic inflammation often persists in specific anatomical locations. The authors highlight that stromal cells, particularly the fibroblasts that define a tissue's architecture, are like…
A theoretical framework for the role of fascia in manual therapy
This theoretical paper explores why different types of manual therapy, such as soft tissue work and joint manipulation, often seem to produce similar results. The authors compare these approaches based on their effects…
Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
This review explores how tumors interact with the lymphatic system to grow and spread. Increased fluid flow from a tumor to nearby lymph nodes does more than just transport cancer cells. This flow also creates mechanica…
Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms
This study investigated the relationship between joint hypermobility and brain structure in 72 healthy volunteers. Using structural brain scans, researchers found that the volume of the amygdala, a brain region importan…
Discovering the link between nutrition and skin aging
This narrative review examines the relationship between nutrition and skin aging, focusing on how specific nutrients may protect against damage from ultraviolet (UV) radiation. The authors describe how antioxidants such…