Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+2014
Dietary Hyaluronic Acid Migrates into the Skin of Rats
Mariko Oe, Koichi Mitsugi, Wataru Odanaka, Hideto Yoshida, Ryosuke Matsuoka, Satoshi Seino, Tomoyuki Kanemitsu, Yasunob…In this animal study, researchers investigated whether orally ingested hyaluronic acid could reach the skin in rats. Using a radio-labeled version of hyaluronic acid, they tracked its path through the body after rats we…
Orally HAHA supplement - A2014
Specific Sizes of Hyaluronan Oligosaccharides Stimulate Fibroblast Migration and Excisional Wound Repair
C Tolg, P Telmer, E TurleyHyaluronan (HA) is a molecule important for wound healing, and its effects appear to depend on its size. In this study using cell cultures and animal models, researchers investigated how specific, small fragments of HA…
fasciahyaluronan molecular sizehyaluronan fragmentswound healing - A2014
The effectiveness of exercise interventions to prevent sports injuries: a systematic review and meta-analysis of randomised controlled trials
Jeppe Bo Lauersen, Ditte Marie Bertelsen, Lars Bo AndersenThis systematic review and meta-analysis examined 25 studies to evaluate which types of exercise best prevent sports injuries. The analysis included over 26,000 participants and data on more than 3,400 injuries. Researc…
exercisesinjury prevention - A2014
Contractile elements in muscular fascial tissue – implications for in-vitro contracture testing for malignant hyperthermia
K Hoppe, Robert Schleip, F Lehmann-Horn, Heike J€ager, Werner KlinglerMalignant hyperthermia (MH) is a rare but serious reaction to general anesthesia, diagnosed using a test on a skeletal muscle biopsy. Since muscle samples also contain fascia, which has contractile cells called myofibro…
myofibroblastsmalignant hyperthermiafascial tissuecontraction - B2014
Neuroreceptor Activation by Vibration-Assisted Tunneling
Ross D Hoehn, David Nichols, Hartmut Neven, Sabre KaisThis theoretical study used quantum chemical modeling to explore how receptors in the nervous system get activated. The researchers propose a model where a molecule's specific vibrations, like a musical key, may be what…
fasciag-proteinpharmacologyGPCRssilicopotency - A2014
Hyaluronan Synthase 2 Protects Skin Fibroblasts against Apoptosis Induced by Environmental Stress
Yan Wang, Mark E Lauer, Sanjay Anand, Judith A Mack, Edward V MaytinSkin fibroblasts need to manage environmental stress, such as UV radiation. This study on mouse cells investigated how hyaluronan (HA) and the enzymes that produce it help fibroblasts survive. Researchers found that cel…
Apoptosis; Caspase; Extracellular Matrix; Fibroblast; Hyaluronan; Skin; Stress. - A+2014
Cartilage repair using human embryonic stem cell-derived chondroprogenitors
AIXIN CHENG, ZOHER KAPACEE, JIANG PENG, SHIBI LU, ROBERT J LUCAS, TIMOTHY E HARDINGHAM, SUSAN J KIMBERIn this animal study, researchers developed a method to turn human embryonic stem cells into cartilage-forming cells under laboratory conditions. These new cells were then implanted into cartilage defects in the knee jo…
arthritistissue regenerationCell transplantationEmbryonic stem cell - B2014
Altered Gene Transcription in Human Cells Treated with Ludox® Silica Nanoparticles
Caterina Fede, Caterina Millino, Beniamina Pacchioni, Barbara Celegato, Chiara Compagnin, Paolo Martini, Francesco Selv…This in vitro study investigated how human lung cells react to exposure to Ludox® silica nanoparticles, which are common in industrial and biomedical applications. Using genetic analysis, researchers observed that the c…
nanoparticles (NPs); cell toxicity; microarray gene expression; pathway analysis - A++2014
Highly sensitive imaging for ultra-weak photon emission from living organisms
Masaki KobayashiThis review article describes research on ultra-weak photon emission (UPE), also known as biophotons, which is faint light spontaneously emitted from living organisms. This light emission is associated with metabolic pr…
biophotonsUltra-weak photon emissionCCDReactive oxygen speciesImaging - A2014
Lumbopelvic muscle activation patterns in three stances under graded loading conditions: Proposing a tensegrity model for load transfer through the sacroiliac joints
Hamed Pardehshenas, Nader Maroufi, Mohammad Ali Sanjari, Mohamad Parnianpour, Stephen M LevinResearchers investigated how lumbopelvic muscles activate to stabilize the sacroiliac (SI) joints under different loads. They compared muscle activity in 30 men during two-legged and one-legged standing while holding we…
fasciasacroiliac jointload transferwire-spoke wheel modelarch theory; Self-bracing - A2014
Mechanotransduction and extracellular matrix homeostasis
Jay D Humphrey, Eric R Dufresne, Martin A SchwartzConnective tissues are dynamic, constantly adapting even at rest. Cells within these tissues continually sense mechanical cues from their environment through a process called mechanotransduction. In response, they maint…
fasciaextracellular matrixIntegrinsmechanosensingmechanoregulation - A++2014
The role of collagen crosslinks in ageing and diabetes - the good, the bad, and the ugly
Jess G Snedeker, Alfonso GautieriThis narrative review explores how glucose in the body can bind to proteins like collagen, a process called glycation. This process creates crosslinks that can change the mechanical properties and function of connective…
collagenCrosslinksageingadvanced glycation endproductstendon mechanics