Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2014
Case study: Could ultrasound and elastography visualized densified areas inside the deep fascia?
Carla Stecco fasciacyteIn this case study, researchers used ultrasound and elastography to visualize the deep fascia of a 40-year-old male with calf pain. The imaging techniques allowed them to see changes in the fascia's gliding, echogenicit…
Fascia; Myofascial pain; Fascial manipulation; Manual therapy; Densification; Gliding; Sliding system - C2014
Monocyte chemoattractant protein-1-induced excitation and sensitization to mechanical stimulation of mechanosensitive C-fiber afferents in rat skin
Asako Kubo, Toru Taguchi, Kazue MizumuraIn this animal study, researchers investigated the effects of the protein MCP-1, which is involved in inflammation, on nerve endings in the skin. Using skin-nerve preparations from rats, they found that applying MCP-1 d…
MCP-1CCL2Single fiber recordingUnmyelinated afferentsMechanical sensitization - A2014
Our Internal Universe
Stephen M LevinThis 2014 entry, titled 'Our Internal Universe' by Stephen M Levin, has not yet been summarized. The title suggests a conceptual exploration of the body's internal environment, possibly from a structural or philosophica…
fasciaTensegrityhapticperception - A++2014
Spatiotemporal Imaging of Glutamate-Induced Biophotonic Activities and Transmission in Neural Circuits
Rendong Tang, Jiapei DaiThis study on mouse brain tissue investigated biophotons, which are ultra-weak light emissions from biological systems. Researchers found that applying the neurotransmitter glutamate caused a significant and long-lastin…
fasciabiophotonsultraweak photons - 1A+2014
Crosstalk between fibroblasts and inflammatory cells
S Van Linthout, K Miteva, C TschöpeThis narrative review describes how fibroblasts, traditionally seen as passive cells that produce extracellular matrix, are increasingly understood as active key players in the immune system. The authors provide an over…
fibroblastMyofibroblastInnate and adaptive immune responseHeart failure - A++2014
Role of reactive oxygen species in ultra-weak photon emission in biological systems
Pavel Pospíšil, Ankush Prasad, Marek RácThis narrative review explores the connection between reactive oxygen species (ROS) and the faint light, or ultra-weak photon emission, that living organisms naturally produce. The authors explain that normal metabolic…
biophotonsChemiluminescenceReactive oxygen specieslipid peroxidationHydroxyl radical - A+++2014
Telocytes revisited
Sanda M Cretoiu, Laurentiu M PopescuThis narrative review summarizes findings on telocytes, a relatively new type of cell found in the interstitial, or connective, tissue of many organs. These cells are defined by their small bodies and extremely long, th…
exosomes/ectosomes; intercellular signaling; regenerative medicine; telocytes; telopodes - A2014
Biotensegrity of the extracellular matrix: physiology, dynamic mechanical balance, and implications in oncology and mechanotherapy
Irene Tadeo, Ana P Berbegall, Luis M Escudero,Tomás Álvaro, Rosa NogueraThis 2014 review article explores the concept of biotensegrity, a principle where cells and tissues maintain structural integrity through a balance of tension and compression. This dynamic mechanical balance involves th…
fasciaextracellular matrixcancerbiotensegritymechanotherapy - A2014
Clinical Relevance of Fascial Tissue and Dysfunctions
Werner Klingler, M Velders, K Hoppe, M Pedro, Robert SchleipFascia is a continuous network of connective tissue that supports the entire body. Traditionally seen as a passive structure, recent research shows it plays a more active role. Fascia contains contractile elements that…
fasciaMyofascial painlumbar fasciadysfunction - A++2014
Ultra-weak photon emission from biological samples: Definition, mechanisms, properties, detection and applications
Michal Cifra, Pavel PospíšilThis review article summarizes the current understanding of ultra-weak photon emission (UPE), a faint light naturally produced by living organisms. This light, a form of chemiluminescence, is generated during normal met…
biophotonsChemiluminescenceOxidative stressSinglet oxygenCharge coupled device - A++2014
Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products
Alfonso Gautieri, Alberto Redaelli, Markus J Buehler, Simone VesentiniAdvanced Glycation End-products (AGEs) are harmful crosslinks that form in collagen with aging and in diabetes, making tissues stiffer. However, the exact location of these crosslinks has been unclear. In this theoretic…
Advanced glycation end-products; Ageing; Atomistic simulations; Collagen; Crosslinks; Diabetes. - A2014
Fat Connected with the Primo Vascular System
Kyoung-Hee Bae, Kwang-Sup SohThis research entry is currently available as a title only, so a detailed summary is not yet possible. The title, "Fat Connected with the Primo Vascular System," suggests an investigation into the relationship between a…
fasciafatadipose tissueprimo vascular system (PVS)