Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesTelocytes in regenerative medicine
This 2015 review article summarizes research on telocytes, a distinct type of cell found in the connective tissue of many organs. These cells form a complex 3D network and are thought to play a key role in guiding stem…
Collagen Crosslinking Does Not Dictate Stiffness in a Transgenic Mouse Model of Skeletal Muscle Fibrosis
In this animal study on mice, researchers investigated why fibrotic, or scarred, skeletal muscle becomes so stiff. While it is known that fibrosis involves an increase in collagen, the amount of collagen alone does not…
Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels
Telocytes are a relatively newly described cell type found in the muscular wall of the uterus, thought to play a role in cell-to-cell signaling. In this laboratory study, researchers examined telocytes from both pregnan…
An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing
This narrative review summarizes research on hydrolysed collagen (HC) and its impact on joint, bone, and skin health. Evidence suggests that these small collagen peptides are highly bioavailable and accumulate in connec…
Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer
This theoretical paper explores the link between cellular energy and cancer. Healthy cells maintain a stable, coherent electrical state through continuous energy production in the mitochondria. The authors propose that…
Hyaluronan Regulates Bone Morphogenetic Protein-7- dependent Prevention and Reversal of Myofibroblast Phenotype
This study on human lung fibroblasts investigated how a protein called BMP7 might counteract fibrosis. Researchers found that BMP7 can prevent and even reverse the formation of myofibroblasts, which are cells that contr…
Modes of cancer cell invasion and the role of the microenvironment
For cancer to spread, or metastasize, tumor cells must first invade the surrounding connective tissue (stroma). This review article describes how cancer cells can move in different ways—either as single cells or in coll…
Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children
This cross-sectional study of over 2000 children in the UK examined the relationship between vitamin C and risk factors for type 2 diabetes. Researchers found that higher levels of vitamin C in the blood were associated…
Manual therapies and hypoalgesia: What are the mechanisms?
This is a title-only entry, and its contents have not yet been summarized. The title suggests the article explores the possible mechanisms behind hypoalgesia, or a decreased sensitivity to pain, following manual therapi…
The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases
This report summarizes research on the effects of "grounding" or "earthing," which involves direct electrically conductive contact with the Earth's surface. The research suggests this contact may influence the body's ph…
Transforming Growth Factor-beta1 (TGF-beta1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts
The transformation of fibroblasts into myofibroblasts is a key part of wound healing, a process largely regulated by the signaling molecule TGF-β1. This study investigated how hyaluronan (HA) and specific receptors (CD4…
BioTensegrity Fascia and the fallacy of biomechanics, Part 2.
In this conceptual article, the second in a series, the author introduces BioTensegrity as an alternative to classical biomechanics. He argues that traditional models of animal and human movement, which date back to the…