Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesMyofascial Trigger Points Then and Now: A Historical and Scientific Perspective
This narrative review explores the historical and scientific understanding of myofascial trigger points (MTrPs) and their role in myofascial pain syndrome (MPS). MTrPs are palpable nodules in taut muscle bands, long con…
Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women
This study investigated how plant sterols from Aloe vera gel affect the skin, using both laboratory tests on human skin cells (fibroblasts) and a clinical trial with women. In the lab, these sterols were found to stimul…
The extracellular matrix: Tools and insights for the “omics” era
This narrative review discusses the extracellular matrix (ECM), the complex network of proteins and molecules that provides structural and chemical support to our cells and tissues. Alterations in the ECM are associated…
Meralgia paresthetica caused by entrapment of the lateral femoral subcutaneous nerve at the fascia lata of the thigh: a case report and literature review
This case report and literature review describe an unusual presentation of meralgia paresthetica, a condition causing numbness and pain in the outer thigh. While the condition typically involves nerve entrapment at the…
The fascial system and exercise intolerance in patients with chronic heart failure: hypothesis of osteopathic treatment
This hypothesis paper proposes a connection between the fascial system and exercise intolerance in people with chronic heart failure. The authors note that heart failure is a complex disease affecting the entire body, l…
Sensory Nerve Fibers Containing Calcitonin Gene-Related Peptide in Gastrocnemius, Latissimus Dorsi and Erector Spinae Muscles and Thoracolumbar Fascia in Mice
In this animal study, researchers investigated sensory nerve fibers containing CGRP, a peptide involved in pain signaling. They compared the presence of these nerve fibers in various muscles (gastrocnemius, latissimus d…
Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments
This lab study investigated why women are more likely to rupture their anterior cruciate ligament (ACL) than men, focusing on the role of estrogen. Researchers used human ACL cells to create engineered ligaments in a la…
Hyaluronic acid and wound healing
In this systematic review, researchers compiled studies on hyaluronic acid (HA) and wound healing published from 2010–2014. The review found that HA is used for tissue regeneration, either alone or in combination with o…
Glycosaminoglycans and Proteoglycans in Palmar Fascia of Patients with Dupuytren
In this experimental study, researchers investigated the role of glycosaminoglycans (GAGs), a type of molecule in connective tissue, in Dupuytren's disease. The team analyzed palmar fascia tissue samples from 23 patient…
Understanding Fibroblasts in Order to Comprehend the Osteopathic Treatment of the Fascia
In this review paper, the authors argue that understanding fibroblasts is essential for comprehending and applying osteopathic treatment of the fascia. As the foundational cells of connective tissue, fibroblasts have ma…
Modelling the mechanoreceptor’s dynamic behaviour
This study developed a computational model to better understand how mechanoreceptors, our body's stretch and pressure sensors, adapt to stimuli. Researchers adapted a model originally used for vision in flies to simulat…
Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
This 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…