Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2016
Human Recombinant Hyaluronidase Injections For Upper Limb Muscle Stiffness in Individuals With Cerebral Injury: A Case Series
Preeti Raghavan, Ying Lu, Mona Mirchandani, Antonio SteccoThis case series investigated injections of the enzyme hyaluronidase to treat upper limb muscle stiffness in 20 individuals with cerebral injury. The researchers hypothesized that an accumulation of hyaluronan in the mu…
fasciaConnective tissueStrokeHypertoniaspasticity - A++2016
Ultra-weak photon emission in healthy subjects and patients with type 2 diabetes: evidence for a non-invasive diagnostic tool
Meina Yang, Wenyu Ding, Yanli Liu, Hua Fan, Rajendra P Bajpai, Jialei Fu, Jingxiang Pang, Xiaolei Zhao, Jinxiang HanAll living organisms emit extremely faint light, known as ultra-weak photon emission (UPE). This study investigated whether these light emissions differ between healthy individuals and people with type 2 diabetes. Resea…
fasciaphoton emissionbiological systemspathological statesUE - A2015
Remodelling the extracellular matrix in development and disease
Caroline Bonnans, Jonathan Chou, Zena WerbThis narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…
fasciaextracellular matrixstiffnessmechanotransductionmatrix remodeling - A2015
Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
S Albeiroti, A Soroosh, C A de la MotteThis 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…
hyaluronanfasciafibrosis - A2015
Primo Vascular System: A Unique Biological System Shifting a Medical Paradigm
Bruno Chikly, Paul Roberts, Jörgen QuaghebeurThis article describes the primo vascular system (PVS), a unique biological system distinct from the arteriovenous and lymphatic systems. Research suggests the PVS has immune and endocrine functions and plays a role in…
fasciaprimo vascular system - A2015
The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases
James L Oschman, Gaétan Chevalier, Richard BrownThis report summarizes research on the effects of "grounding" or "earthing," which involves direct electrically conductive contact with the Earth's surface. The research suggests this contact may influence the body's ph…
fasciachronic inflammationimmune systemwound repairwhite blood cells - A+2015
A unifying neuro-fasciagenic model of somatic dysfunction - Underlying mechanisms and treatment - Part II
Paolo TozziThis review paper proposes a new, unifying "neuro-fasciagenic" model for understanding somatic dysfunction. The author argues for a shift in perspective, moving from a purely neurological explanation to one where fascia…
fasciaManual Therapysomatic dysfunctionfascial dysfunctionfascial mechanisms - A2015
The fascial system and exercise intolerance in patients with chronic heart failure: hypothesis of osteopathic treatment
Bruno Bordoni, F MarelliThis hypothesis paper proposes a connection between the fascial system and exercise intolerance in people with chronic heart failure. The authors note that heart failure is a complex disease affecting the entire body, l…
fasciaManual TherapyOsteopathicfatiguechronic heart failure - A2015
Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer
Jirí Pokorný, Jan Pokorný, Alberto Foletti, Jitka Kobilková, Jan Vrba, Jan Vrba JrThis theoretical paper explores the link between cellular energy and cancer. Healthy cells maintain a stable, coherent electrical state through continuous energy production in the mitochondria. The authors propose that…
fasciacancer biophysicsmitochondrial dysfunctionwater orderingmicrotubule oscillations - A2015
Reflections on osteopathic fascia treatment in the peripheral nervous system
Bruno Bordoni, Giovanni BordoniIn this reflective article, the authors discuss the fascia of the peripheral nervous system. They explain that nerves are enclosed in several layers of fascia that must be able to slide, and that impeded sliding can be…
fasciapainfascial treatmentnerve palpation - A2015
Innervation Changes Induced by Inflammation of the Thoracolumbar Fascia
U Hoheisel, J Rosner, S MenseThis animal study investigated how inflammation affects the nerves in the thoracolumbar fascia (TLF) of rats. Researchers induced inflammation in the TLF and compared its nerve fiber density to that of healthy fascia. W…
inflammationfasciafasciitisfascia innervationsympathetic fibers - A2015
Hyaluronan, inflammation and breast cancer progression
Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthyThis narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…
hyaluronaninflammationCD44fasciaBreast cancer