Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- B2016
Limited mechanical effects of intermuscular myofascial connections within the intact rat anterior crural compartment
Chris Tijs, Jaap H van Dieën, Huub MaasIn this animal study, researchers investigated the connective tissue links between two lower leg muscles in rats, the tibialis anterior and extensor digitorum longus. The goal was to see if these connections significant…
Tibialis anteriorExtensor digitorum longus3D kineticsCo-activationMechanical interaction - A2016
Intermuscular force transmission along myofascial chains: a systematic review
Frieder Krause, Jan Wilke, Lutz Vogt, Winfried BanzerThis systematic review examined evidence for force transmission along continuous lines of muscle and fascia, often called myofascial chains. Researchers analyzed nine studies of moderate to excellent quality that invest…
anatomy trains; fascia; myofascial continuity; tension transfer - A2016
Remote effects of lower limb stretching: preliminary evidence for myofascial connectivity?
Jan Wilke, Daniel Niederer, Lutz Vogt, Winfried BanzerThis study investigated whether stretching the lower body could affect neck mobility. Twenty-six healthy participants were divided into two groups, with one group performing static stretches for the calf and hamstring m…
Myofascial chains; force transmission; fascia; meridians - A2016
Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase
Sebastian Kalamajski, Dominique Bihan, Arkadiusz Bonna, Kristofer Rubin, Richard W FarndaleFibrosis is characterized by a dense and stiff collagen matrix, formed through a cross-linking process driven by the enzyme lysyl oxidase (LOX). This study investigated the role of another protein, fibromodulin, in this…
fibrosiscollagen cross-linkingfibromodulinlysyl oxidase - A2016
The tongue after whiplash: case report and osteopathic treatment
Bruno Bordoni, Fabiola Marelli, Bruno MorabitoThis case report describes a 30-year-old man who experienced neck pain during swallowing and had a reduced ability to open his mouth following a whiplash injury. He was treated with osteopathic manual techniques directe…
fasciafascial releasetongueindirect osteopathic techniques - C2016
Protein—glycosaminoglycan interaction networks: Focus on heparan sulfate
Sylvie Ricard-BlumThis research overview describes a project focused on glycosaminoglycans (GAGs), complex sugars found on the cell surface and in the extracellular matrix. Specifically, it investigates heparan sulfate and how it interac…
extracellular matrixHeparan sulfateInteraction networksInteraction databasesSurface plasmon resonance - A+2016
Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women: A Randomized Controlled Clinical Trial
Azam Jokar, Tayebe Davari, Nasrin Asadi, Fateme Ahmadi, Sedighe ForuhariThis randomized controlled clinical trial compared the effectiveness of hyaluronic acid vaginal cream with conjugated estrogen cream for treating vaginal atrophy in menopausal women. Over an eight-week period, researche…
Atrophic vaginitis; Estrogen; Hyaluronic acid; Menopause - A++2016
Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity
Denise Morais da Fonseca, Timothy W Hand, Seong-Ji Han, Michael Y Gerner, Arielle Glatman Zaretsky, Allyson L Byrd, Oli…A single acute infection can have long-term consequences for tissue-specific immunity, even after the pathogen is cleared. This study found that following a gut infection with Yersinia pseudotuberculosis, sustained infl…
Gut microbiome / Immunity - A2016
Human Recombinant Hyaluronidase Injections For Upper Limb Muscle Stiffness in Individuals With Cerebral Injury: A Case Series
Preeti Raghavan, Ying Lu, Mona Mirchandani, Antonio SteccoThis case series investigated injections of the enzyme hyaluronidase to treat upper limb muscle stiffness in 20 individuals with cerebral injury. The researchers hypothesized that an accumulation of hyaluronan in the mu…
fasciaConnective tissueStrokeHypertoniaspasticity - A2016
Hyaluronan production and molecular weight is enhanced in pathway-engineered strains of lactate dehydrogenase-deficient Lactococcus lactis
Mandeep Kaur, Guhan JayaramanResearchers are exploring ways to use engineered bacteria to produce hyaluronic acid (HA), but the yield and molecular weight have often been limited. Previous work suggested that excessive lactate production might be t…
Hyaluronic acid molecular weightLactococcus lactisLactate dehydrogenase mutantNADþ/NADH ratioHA-precursor concentration ratio - B2016
Hyaluronic Acid in Inflammation and Tissue Regeneration
Malgorzata Litwiniuk, Alicja Krejner, Tomasz GrzelaThis review article summarizes the role of hyaluronic acid (HA) in tissue healing. As a main component of the extracellular matrix, HA is a key player in tissue regeneration. Interestingly, its effects depend on its mol…
hyaluronic acid; extracellular matrix; wound healing; Inflammation - A++2016
Whole-Body and Local Muscle Vibration Immediately Improve Quadriceps Function in Individuals With Anterior Cruciate Ligament Reconstruction
Derek N Pamukoff, Brian Pietrosimone, Michael D Lewek, Eric D Ryan, Paul S Weinhold, Dustin R Lee, J Troy BlackburnThis randomized crossover trial investigated the immediate effects of vibration on quadriceps function in individuals with a prior anterior cruciate ligament (ACL) reconstruction. Twenty participants performed isometric…
Musclevibrationsligament injury