Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesNutraceutical supplement in the management of tendinopathies: a systematic review
This systematic review examines the effects of various nutraceuticals, such as glucosamine, chondroitin, vitamin C, and curcumin, in managing tendon disorders. While preclinical research on cells and animals shows promi…
Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration
This study investigated how the lubricant hyaluronan in knee joint fluid changes with age and cartilage wear. Researchers analyzed synovial fluid from human donors aged 23 to 91 without diagnosed osteoarthritis. They fo…
Hyaluronan production and molecular weight is enhanced in pathway-engineered strains of lactate dehydrogenase-deficient Lactococcus lactis
Researchers are exploring ways to use engineered bacteria to produce hyaluronic acid (HA), but the yield and molecular weight have often been limited. Previous work suggested that excessive lactate production might be t…
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
This review article describes matrix metalloproteinases (MMPs), the primary enzymes responsible for breaking down collagen in the extracellular matrix. This breakdown process is normal and necessary for tissue remodelin…
Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation
This perspective article explores the field of mechanobiology and how physical therapists use mechanical forces to promote tissue healing. It explains that cells in our muscles, bones, and tendons respond to physical st…
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
This narrative review explores the link between oxidative stress and inflammation, focusing on how plant-derived polyphenols may mitigate these processes. Oxidative stress occurs when reactive oxygen species overwhelm t…
Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies
This review examines the relationship between vitamin C and heart health by analyzing data from epidemiological studies and clinical trials. Research suggests that vitamin C may protect blood vessels by preventing the o…
Can fascia’s characteristics be influenced by manual therapy
This theoretical essay investigates the fundamental properties of collagen, a key component of fascia. The author explores how manual therapy might relate to the necessity of maintaining collagen's strength under load.…
Ultra-weak photon emission in healthy subjects and patients with type 2 diabetes: evidence for a non-invasive diagnostic tool
All living organisms emit extremely faint light, known as ultra-weak photon emission (UPE). This study investigated whether these light emissions differ between healthy individuals and people with type 2 diabetes. Resea…
Endogenous spontaneous ultraweek photon emission in the formation of eye-specific retinogeniculate projections before birth
It has long been a puzzle how the intricate nerve connections between the eye and brain form so accurately before birth, without any visual input. This theoretical paper proposes a novel explanation for this phenomenon.…
Ultra-weak photon emission of hands in aging prediction
This study, for which a full summary is not yet available, appears to investigate the relationship between ultra-weak photon emissions from the hands and the biological aging process. The title suggests researchers expl…
Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase
Fibrosis is characterized by a dense and stiff collagen matrix, formed through a cross-linking process driven by the enzyme lysyl oxidase (LOX). This study investigated the role of another protein, fibromodulin, in this…