Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A++2016
Ultra-weak photon emission in healthy subjects and patients with type 2 diabetes: evidence for a non-invasive diagnostic tool
Meina Yang, Wenyu Ding, Yanli Liu, Hua Fan, Rajendra P Bajpai, Jialei Fu, Jingxiang Pang, Xiaolei Zhao, Jinxiang HanAll living organisms emit extremely faint light, known as ultra-weak photon emission (UPE). This study investigated whether these light emissions differ between healthy individuals and people with type 2 diabetes. Resea…
fasciaphoton emissionbiological systemspathological statesUE - A+++2016
Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells
Brett A Morris, Brian Burkel, Suzanne M Ponik, Jing Fan, John S Condeelis, Julio A Aguirre-Ghiso, James Castracane, Joh…This study used a 3D in vitro model to investigate how the density of the collagen matrix influences the metabolism of breast cancer cells. The researchers observed that a high-density extracellular matrix drives a meta…
Breast cancer; Collagen; Matrix density; Metabolism - A+2016
The relationship between pelvic alignment and dysmenorrhea
Moon-Jeong Kim, Il-Hun Baek, Bong-Oh GooThis study investigated the relationship between pelvic alignment and dysmenorrhea (menstrual pain). Researchers compared 102 women, divided into a group with menstrual pain and a group without, using 4D imaging to meas…
AlignmentDysmenorrheaPelvic torsion - A+++2016
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
In Young Choi, Laura Piccio, Patra Childress, Bryan Bollman, Arko Ghosh, Sebastian Brandhorst, Jorge Suarez, Andreas Mi…This study investigates how a periodic fasting-mimicking diet (FMD) affects symptoms of multiple sclerosis (MS) using mouse models and preliminary human trials. In animal models, the diet reduced inflammation and promot…
Fasting-mimicking diet; Intermittent fasting; Time-restricted eating; autoimmunity; multiple sclerosis - A2016
The Physical Mechanism for Retinal Discrete Dark Noise: Thermal Activation or Cellular Ultraweak Photon Emission?
Vahid Salari, Felix Scholkmann, Istvan Bokkon, Farhad Shahbazi, Jack TuszynskiThe visual 'static' or 'noise' we perceive in complete darkness has long been a puzzle. The conventional explanation is that random thermal energy causes photoreceptor cells in the retina to fire, but this model doesn't…
Biophotons - A+2016
Acute effects of muscle stretching on physical performance, range of motion, and injury incidence in healthy active individuals: a systematic review
David G Behm, Anthony J Blazevich, Anthony D Kay, Malachy McHughThis systematic review examines how different types of stretching (static, dynamic, and PNF) affect performance, range of motion (ROM), and injury risk in healthy individuals. The findings suggest that static stretching…
ballistic stretch; dynamic stretch; facilitation neuromusculaire proprioceptive; flexibility; flexibilité; proprioceptive neuromuscular facilitation; static stretch; warm-up - A++2016
Estrogen and Pelvic Organ Prolapse
Ling Zhou, Anna Junjie Shangguan, Stacy Ann Kujawa, Katarzyna Bochenska, Lanmei Zhang, Serdar E Bulun, Hong ZhaoThis narrative review explores the relationship between estrogen and pelvic organ prolapse (POP), a condition where pelvic organs descend from their normal positions. Research suggests that low estrogen levels, particul…
Pelvic organ prolapse; Estrogen; Estrogen receptor; Collagen; Matrix metalloproteinases - C2016
Coordinated integrin activation by actin-dependent force during T-cell migration
P Nordenfelt, H L Elliott, T A SpringerResearchers investigated how immune cells, specifically T-cells, generate the force needed to move. Using fluorescent tension sensors, they visualized the tension within integrins, which are proteins that help cells gri…
cytoskeletonIntegrinsactin - A+++2016
Nutraceutical supplement in the management of tendinopathies: a systematic review
Federico Fusini, Salvatore Bisicchia, Carlo Bottegoni, Antonio Gigante, Fabio Zanchini, Alberto BusilacchiThis systematic review examines the effects of various nutraceuticals, such as glucosamine, chondroitin, vitamin C, and curcumin, in managing tendon disorders. While preclinical research on cells and animals shows promi…
arginine alpha-keto-glutarate; ascorbate; boswellic acid; curcumin; oral supplement; tendon disorder - A++2016
Three Case Reports of Successful Vibration Therapy of the Plantar Fascia for Spasticity Due to Cerebral Palsy-Like Syndrome, Fetal-Type Minamata Disease
Fusako Usuki, Satsuki TohyamaThis series of case reports describes the long-term effects of vibration therapy on lower-limb spasticity in three patients with fetal-type Minamata disease, a condition with symptoms similar to cerebral palsy. Research…
spasticityvibration therapyFDM - 1A+2016
STRETCHING IMPACTS INFLAMMATION RESOLUTION IN CONNECTIVE TISSUE
L Berrueta, I Muskaj, S Olenich, T Butler, G J Badger, R A Colas, M Spite, C N Serhan, H M LangevinIn this animal study, researchers investigated the effect of stretching on acute inflammation in the connective tissue of rats. After inducing local inflammation in the rats' backs, one group was subjected to twice-dail…
Stretching; SPM; Resolvin; Inflammation; Connective tissue - B2016
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
Agata Jabłońska-Trypuć, Marzena Matejczyk, Stanisław RosochackiThis review article describes matrix metalloproteinases (MMPs), the primary enzymes responsible for breaking down collagen in the extracellular matrix. This breakdown process is normal and necessary for tissue remodelin…
cancercollagenAngiogenesisapoptosismetalloproteinase