Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2017
Implications of immune dysfunction on endometriosis associated infertility
Jessica E Miller, Soo Hyun Ahn, Stephany P Monsanto, Kasra Khalaj, Madhuri Koti, Chandrakant TayadeThis literature review explores the link between endometriosis and infertility, a common issue for which the cause is not fully understood. The authors suggest that dysfunction in the immune system plays a significant r…
cytokines; endometriosis; infertility; inflammation; oxidative stress. - A++2017
Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice
Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, Haile MaThis animal study investigated how oral supplementation of collagen hydrolysates derived from fish scales affected chronological skin aging in mice over six months. The researchers found that mice receiving collagen in…
chronological aging; collagen hydrolysates; histological structure; oxidative stress; skin condition; visual appearance - A+2017
Hyaluronan as a therapeutic target in human diseases
Jiurong Liang, Dianhua Jiang, Paul W NobleThis narrative review explores the role of hyaluronan, a major component of the extracellular matrix involved in tissue injury and repair. Its function varies significantly with its size; fragmented hyaluronan can promo…
hyaluronan - A+2017
Oxidative Stress and Endometriosis: A Systematic Review of the Literature
Gennaro Scutiero, Piergiorgio Iannone, Giulia Bernardi, Gloria Bonaccorsi, Savino Spadaro, Carlo Alberto Volta, Pantale…This systematic review explores the connection between oxidative stress and endometriosis, a condition where uterine-like tissue grows outside the uterus, causing pain and infertility. Oxidative stress is an imbalance b…
Oxidative stressendometriosisROS - A+++2017
Activation of type 2 cannabinoid receptor (CB2R) by selective agonists regulates the deposition and remodelling of the extracellular matrix
Tao Guan, Guiyang Zhao, Honghui Duan, Yang Liu, Feng ZhaoThis in vitro study investigated how activating the type 2 cannabinoid receptor (CB2R) affects scar formation in eye connective tissue after surgery. Researchers found that human Tenon’s fibroblasts express these recept…
Matrix metalloproteinase 1 (MMP-1); Tenon’s fibroblasts; Transforming growth factor-β1; Type 2 cannabinoid receptor (CB2R); Wound healing - A2017
Amino acid composition in determination of collagen origin and assessment of physical factors effects
Marlena Gauza-Włodarczyk, Leszek Kubisz, Dariusz WłodarczykThis study examines the amino acid composition of collagen derived from various sources, including fish skin, bovine Achilles tendon, and bone tissue. The researchers found that the levels of hydroxyproline, a unique am…
hydroxyprolineBone collagenFish skin collagenIrradiationPolymer - B2017
Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism
Rosilene Cristina Rossetto Burgos, Johannes Cornelius Schoeman, Lennart Jan van Winden, Kateřina Červinková, Rawi Ramau…This laboratory study investigated a method for measuring oxidative stress, a process linked to many diseases. Researchers used a technique called ultra-weak photon emission (UPE) to monitor human cells in a dish after…
Ultra-weak photon emission - A+++2017
Role of Magnesium in Vitamin D Activation and Function
Anne Marie Uwitonze, Mohammed S RazzaqueIn this scientific review, the authors discuss how magnesium and vitamin D work together in the body. Magnesium acts as a cofactor, meaning it helps activate the enzymes that metabolize vitamin D in the liver and kidney…
Vitamin D activationmagnesiumcalcidefiolcalcitriol - A2017
What's in a name: Myofascial Release or Myofascial Induction?
Leon ChaitowThis commentary discusses two terms for a similar manual therapy technique: Myofascial Release (MFR) and Myofascial Induction Therapy (MIT). The author notes that while the techniques are virtually identical, the names…
Myofascial releaseMyofascial Induction therapy - C2017
Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface
KA Khan, AJ Naylor, A Khan, PJ Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, CD Buckley, BE Willcox, F Mohammed ,…Researchers investigated how certain proteins interact to form new blood vessels, a process called angiogenesis that is crucial for tumor growth. This study, which included lab experiments and mouse models, identified a…
fasciaextracellular matrixendotheliumC-type lectintumor angiogenesis - A+++2017
Resveratrol regulates body weight in healthy and ovariectomized rats
Rupali Sharma, Neel Kamal Sharma, M ThungapathraThis animal study on rats investigated how the plant compound resveratrol affects body weight in both healthy subjects and those who had undergone ovariectomy, a model for menopause. The results suggest that resveratrol…
OVX; Ovariectomy; Resveratrol; Soya free diet - A2017
Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles
Uma Thanigai Arasu, Riikka Kärnä, Kai Härkönen, Sanna Oikari, Arto Koistinen, Heikki Kröger, Chengjuan Qu, Mikko J Lamm…Mesenchymal stem cells (MSCs) are known to help with tissue repair, partly by releasing tiny packages called extracellular vesicles (EVs). This study investigated the connection between these EVs and hyaluronan (HA), a…
Hyaluronan; CD44; Extracellular vesicle; Stem cell; Filopodia; Hyaluronan synthase