Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesMicroscopic anatomy of the visceral fasciae
Researchers examined the microscopic structure of visceral fascia—the connective tissue surrounding internal organs—from eight cadavers. They analyzed samples from the thorax, abdomen, and around organs like the heart,…
Concurrent validity of pain scales in individuals with myofascial pain and fibromyalgia
Researchers investigated the reliability of two common tools for measuring pain: the Numeric Pain Rating Scale (NPRS), where patients rate pain from 0 to 10, and the Visual Analog Scale (VAS). The study included 60 part…
Telocytes: Connective tissue repair and communication cells
This commentary highlights a newly identified type of connective tissue cell called a telocyte. We already know that other cells, like fibroblasts, respond to mechanical forces from manual therapy, influencing tissue re…
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate
In this animal study, researchers examined mitochondrial function in a mouse model of Alzheimer's disease and in mice with low levels of vitamin C (ascorbate). The results indicated that both the presence of amyloid (as…
Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels
This narrative review explores Piezo1 and Piezo2, specialized proteins that act as the body's primary mechanical sensors. These ion channels convert physical forces like touch, tension, and fluid flow into electrical si…
Activation of type 2 cannabinoid receptor (CB2R) by selective agonists regulates the deposition and remodelling of the extracellular matrix
This in vitro study investigated how activating the type 2 cannabinoid receptor (CB2R) affects scar formation in eye connective tissue after surgery. Researchers found that human Tenon’s fibroblasts express these recept…
CT arthrography of adhesive capsulitis of the shoulder: Are MR signs applicable?
This retrospective study investigated whether signs of adhesive capsulitis (frozen shoulder) typically seen on MRI could also be identified using CT arthrography (CTA). Researchers compared CTA scans from 22 patients wi…
Hypermobile Ehlers–Danlos Syndrome (a.k.a. Ehlers–Danlos Syndrome Type III and Ehlers–Danlos Syndrome Hypermobility Type): Clinical Description and Natural History
This 2017 review summarizes the clinical understanding of hypermobile Ehlers-Danlos syndrome (hEDS), thought to be the most common hereditary disorder of connective tissue. It is primarily characterized by musculoskelet…
Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
Researchers are investigating the role of brain immune cells called microglia in fibromyalgia. This study used a new technique to create microglia-like cells from the blood of people with fibromyalgia and healthy indivi…
Adhesive Capsulitis of the Shoulder Joint: Value of Glenohumeral Distance on Magnetic Resonance Arthrography
Researchers investigated a new way to help diagnose adhesive capsulitis (frozen shoulder) using a specific type of MRI called MR arthrography. They measured the distance between the ball and socket of the shoulder joint…
Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
This systematic review and meta-analysis compiled data from 22 randomized controlled trials to assess the effect of vitamin C supplementation on glycemic control. Overall, the researchers found no significant effect on…
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma
This study investigated signs of inflammation in people with fibromyalgia (FM). Researchers analyzed 92 different inflammation-related proteins in both blood plasma and cerebrospinal fluid from 40 FM patients, comparing…