Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesTelocytes heterogeneity: From cellular morphology to functional evidence
This review discusses telocytes, a recently identified type of cell found throughout the connective tissue (stroma) of vertebrates. They are characterized by extremely long, thin extensions called telopodes, which form…
Muscle strength and stiffness in resistance exercise: Force transmission in tissues
Researchers used a mathematical model to estimate how forces are transmitted through the quadriceps muscle during isometric resistance exercises. They specifically looked at how knee angle affects muscle stiffness, stre…
Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis
This animal study investigated the effects of stretching on systemic sclerosis, a condition that causes skin inflammation and fibrosis. Using a mouse model of the disease, researchers found that ten minutes of daily str…
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate
In this animal study, researchers examined mitochondrial function in a mouse model of Alzheimer's disease and in mice with low levels of vitamin C (ascorbate). The results indicated that both the presence of amyloid (as…
Microscopic anatomy of the visceral fasciae
Researchers examined the microscopic structure of visceral fascia—the connective tissue surrounding internal organs—from eight cadavers. They analyzed samples from the thorax, abdomen, and around organs like the heart,…
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study
In this retrospective before-after study, researchers investigated the effect of a combination therapy of intravenous vitamin C, hydrocortisone, and thiamine for patients with severe sepsis and septic shock. They compar…
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
This study investigated vitamin C levels in 44 critically ill patients in an intensive care unit (ICU). Researchers found that most patients had low vitamin C levels (hypovitaminosis C), and one-third were severely defi…
Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism
This laboratory study investigated a method for measuring oxidative stress, a process linked to many diseases. Researchers used a technique called ultra-weak photon emission (UPE) to monitor human cells in a dish after…
The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review
This narrative review examines the role of the lumbodorsal fascia as a potential source of low back pain. Research shows this fascia contains pain-sensing nerve endings, which may be morphologically altered in people wi…
Piezoelectric material – A promising approach for bone and cartilage regeneration
This paper outlines a novel hypothesis for regenerating bone and cartilage, two weight-bearing tissues that are challenging to repair. Current treatments for damage from trauma or diseases like osteoarthritis have signi…
Calcium Signaling in Interstitial Cells: Focus on Telocytes
This narrative review describes current knowledge on calcium signaling in a group of cells called interstitial cells, with a special focus on telocytes. These cells and their calcium signals are important for generating…
The significance of closed kinematic chains to biological movement and dynamic stability
Biomechanical research has long focused on the body as a system of levers, but this review highlights the importance of "closed kinematic chains" (CKCs). These are continuous mechanical loops that couple multiple parts…