Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesHyaluronan in Tissue Injury and Repair
This 2007 review article explores the complex role of hyaluronan (HA), a component of the extracellular matrix, in tissue injury and repair. The authors describe how HA's function depends on its size: while the large, n…
Hyaluronan fragments: An information-rich system
This narrative review explores the diverse roles of hyaluronan (HA), a key component of the extracellular matrix. Despite its simple chemical structure, HA's biological function changes dramatically and often opposition…
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2
Hyaluronan (HA) is a common component of the body's connective tissue. This study investigates how different sizes of HA molecules affect the immune system. When tissue is injured, large HA molecules are broken down int…
Experimental approaches to hyaluronan structure
In this literature review, researchers summarize experimental studies on the structure of hyaluronan (HA). In conditions similar to the body (neutral, physiological salt solution), HA behaves as a long, semi-flexible po…
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
During inflammation, components of our connective tissue like hyaluronic acid (HA) can break down. This study investigated how small fragments of HA affect the immune system. Researchers found that these fragments activ…
Mammalian Hyaluronan Synthases
This 2002 review article describes the three enzymes that produce hyaluronan (HA) in mammals: HAS1, HAS2, and HAS3. These three enzyme isoforms have different characteristics and create different sizes of HA molecules.…
Hyaluronan and its catabolic products in tissue injury and repair
This narrative review explores the role of hyaluronan (HA), a common component of connective tissue, in the body's response to injury. In healthy tissues, HA exists as a large molecule that helps maintain structural int…
Angiogenic oligosaccharides of hyaluronan enhance the production of collagens by endothelial cells
This study investigated how small fragments of hyaluronan (HA) affect collagen production during the formation of new blood vessels, a process called angiogenesis. Researchers observed that applying these HA fragments t…