Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- 1A+2007
Hyaluronan in Tissue Injury and Repair
Dianhua Jiang, Jiurong Liang, Paul W NobleThis 2007 review article explores the complex role of hyaluronan (HA), a component of the extracellular matrix, in tissue injury and repair. The authors describe how HA's function depends on its size: while the large, n…
hyaluronaninflammationtissue repair - B2006
Hyaluronan fragments: An information-rich system
Robert Stern, Akira A Asari, Kazuki N SugaharaThis narrative review explores the diverse roles of hyaluronan (HA), a key component of the extracellular matrix. Despite its simple chemical structure, HA's biological function changes dramatically and often opposition…
hyaluronanextracellular matrixglycosaminoglycanshyaluronidaseOligosaccharides - B2006
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2
Kara A Scheibner, Michael A Lutz, Sada Boodoo, Matthew J Fenton, Jonathan D Powell, Maureen R HortonHyaluronan (HA) is a common component of the body's connective tissue. This study investigates how different sizes of HA molecules affect the immune system. When tissue is injured, large HA molecules are broken down int…
hyaluronanhafasciaextracellular matrixtisssue - B2004
Experimental approaches to hyaluronan structure
Mary K Cowman, Shiro MatsuokaIn this literature review, researchers summarize experimental studies on the structure of hyaluronan (HA). In conditions similar to the body (neutral, physiological salt solution), HA behaves as a long, semi-flexible po…
hyaluronanviscosityPolysaccharidePolymer solutionOsmotic pressure - B2002
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Christian Termeer, Frauke Benedix, Jonathon Sleeman, Christina Fieber, Ursula Voith, Thomas Ahrens, Kensuke Miyake, Mar…During inflammation, components of our connective tissue like hyaluronic acid (HA) can break down. This study investigated how small fragments of HA affect the immune system. Researchers found that these fragments activ…
hyaluronanextracellular matrixtoll-like receptorsglycosaminoglycansdendritic cells - B2002
Mammalian Hyaluronan Synthases
Naoki Itano, Koji KimataThis 2002 review article describes the three enzymes that produce hyaluronan (HA) in mammals: HAS1, HAS2, and HAS3. These three enzyme isoforms have different characteristics and create different sizes of HA molecules.…
hyaluronanBiosynthesisglycosyltransferasesynthasesHAS isoforms - 1A+2001
Hyaluronan and its catabolic products in tissue injury and repair
P W NobleThis narrative review explores the role of hyaluronan (HA), a common component of connective tissue, in the body's response to injury. In healthy tissues, HA exists as a large molecule that helps maintain structural int…
hyaluronaninflammationCD44respons to injury - A1993
Angiogenic oligosaccharides of hyaluronan enhance the production of collagens by endothelial cells
P Rooney, M Wang, P Kumar, S KumarThis study investigated how small fragments of hyaluronan (HA) affect collagen production during the formation of new blood vessels, a process called angiogenesis. Researchers observed that applying these HA fragments t…
hyaluronancollagenAngiogenesis