Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2018
The anatomical relationships of the tongue with the body system
Bruno Bordoni, Bruno Morabito, Roberto Mitrano, Marta Simonelli, Anastasia ToccafondiIn this review article, the authors examine the tongue's functions and its anatomical connections to the rest of the body. The tongue is not only essential for swallowing, breathing, and speaking, but it also affects po…
fasciadiaphragmphysiotherapytonguespeech therapy - A+++2018
Effects of local vibration therapy on various performance parameters: a narrative literature review
Darrin Germann, Amr El Bouse, Jordan Shnier, Nader Abdelkader, Mohsen KazemiThis narrative literature review examines how local muscle vibration (LMV) affects performance parameters such as strength, power, and range of motion. By applying vibrations directly to a specific muscle or tendon, LMV…
chiropractic; local muscle vibration; performance; vibration. - A+++2018
Effects of Plantar Vibration on Bone and Deep Fascia in a Rat Hindlimb Unloading Model of Disuse
Yunfei Huang, Yubo Fan, Michele Salanova, Xiao Yang, Lianwen Sun, Dieter BlottnerThis animal study investigated how disuse affects deep fascia and bone, and whether vibration could counteract these effects. Researchers used a rat model where hindlimbs were unloaded for 21 days to simulate disuse, wh…
extracellular matrixcollagenBonedeep fasciaBiomechanics - A2018
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini , Sanna Pasonen-SeppänenAstrocytomas are the most common type of brain tumor in adults. In this retrospective study, researchers investigated hyaluronan, a key component of the brain's extracellular matrix, and its related enzymes in 163 tumor…
hyaluronanHyaluronan synthaseAstrocytomaPrognosisGlioma - 1A+++2018
Quantification of hyaluronan in human fasciae: variations with function and anatomical site
Caterina Fede, A Angelini, R Stern, V Macchi, A Porzionato, P Ruggieri, R De Caro, Carla SteccoThis study quantified for the first time the amount of hyaluronan (HA), a key lubricant, in human fascia from different parts of the body. Since HA is essential for the smooth gliding between fascial layers, understandi…
densification; extracellular matrix; fascia; fibrosis; gliding; hyaluronan; myofascial pain - A2018
The influence of breathing on the central nervous system
Bruno Bordoni, Shahin Purgol, Annalisa Bizzarri, Maddalena Modica, Bruno MorabitoThis narrative review explores the diaphragm's extensive influence on the central nervous system. The authors discuss how the rhythm of our breath can physically move the brain, alter patterns of neural oscillation, and…
diaphragmbreathingphrenic nervevagus nerveneural oscillation - A2018
Therapeutic potentials of superoxide dismutase
H YounusThis narrative review explores the therapeutic potential of superoxide dismutases (SODs), a group of enzymes that serve as a crucial antioxidant defense against oxidative stress in the body. The author discusses the rol…
Oxidative stresssuperoxide dismutasetherapeutic effects - A+++2018
Fascial tissue research in sports medicine: from molecules to tissue adaptation, injury and diagnostics: consensus statement
Martina Zügel, Constantinos N Maganaris, Jan Wilke, Karin Jurkat-Rott, Werner Klingler, Scott C Wearing, Thomas Findley…This consensus statement reviews the current state of knowledge on fascial tissue in sports medicine. It describes fascia as a body-wide network of connective tissue that integrates all body systems and is crucial for m…
fasciainjurysports medicine - C2018
Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease
Geir Christensen, Kate M Heruma, Ida G LundeIn this review article, the authors discuss the role of proteoglycans in heart disease. Remodeling of the heart's extracellular matrix, which is common in several cardiac diseases, can lead to fibrosis and impaired func…
extracellular matrixHeart failureheartProteoglycansSyndecan - 1A+++2018
Emission of Biophotons and Adjustable Sounds by the Fascial System: Review and Reflections for Manual Therapy
Bruno Bordoni, F Marelli, B Morabito, B SacconiIn this narrative review, the authors explore how fascia, the web of connective tissue enveloping everything in the body, might communicate. They discuss research suggesting the fascial system may emit faint light parti…
fasciaMuscleManual TherapyMyofascialOsteopathic - A2018
Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study
Won-Young Kim, Eun-Jung Jo, Jung Seop Eom, Jeongha Mok, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha LeeThis cohort study investigated a combination therapy of vitamin C, hydrocortisone, and thiamine for ICU patients with severe pneumonia. Researchers compared a group receiving the treatment to a control group from the pr…
Ascorbic acidHydrocortisoneIntensive care unitPneumoniaThiamine - A++2018
Biomechanical findings in horses showing asymmetrical vertical excursions of the withers at walk
Anna Byström, Agneta Egenvall, Lars Roepstorff, Marie Rhodin, Filipe S Bragança, Elin Hernlund, René van Weeren, Michae…This study investigated movement patterns in seven sound high-level dressage horses to understand why the withers move asymmetrically at a walk. Researchers found that vertical asymmetry in the withers was not caused by…
asymmetry