Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesAge-related changes in leg proprioception: implications for postural control
This narrative review examines how aging affects proprioception—the body's sense of its own position and movement—and its implications for balance. To maintain an upright stance, the brain relies on signals from recepto…
The neural basis of the senses of effort, force and heaviness
This narrative review explores how we sense effort, force, and heaviness during muscle contraction. Traditionally, these sensations were thought to originate in the brain from copies of motor commands. However, new evid…
Mechanics and structural stability of the collagen triple helix
This narrative review explores the mechanical properties of collagen, the body's primary structural protein. Collagen's unique triple helix structure is believed to be the source of its stability and resilience in tissu…
Lipedema: A Call to Action!
This narrative review summarizes the current understanding of lipedema, a chronic and progressive disease primarily affecting women. It is characterized by a painful, abnormal distribution of fat in the limbs, which oft…
Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats
This animal study investigated the link between gut bacteria, the immune system, and blood pressure in rats. Researchers transplanted gut microbiota between spontaneously hypertensive rats and rats with normal blood pre…
Genetics of lipedema: new perspectives on genetic research and molecular diagnoses
This 2019 review explored the genetic basis of lipedema. The researchers summarized existing knowledge to highlight the need for a genetic test to aid in diagnosis. They identified several genetic factors that may be re…
Collagen changes in pelvic support tissues in women with pelvic organ prolapse
This narrative review summarizes research on how changes in collagen are linked to pelvic organ prolapse in women. Collagen is a critical component of the pelvic floor, providing essential supportive functions. Studies…
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure
This randomized controlled trial investigated whether intravenous vitamin C could help patients with sepsis and severe acute respiratory failure. Researchers gave 167 patients either a high-dose vitamin C infusion or a…
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
This meta-analysis reviewed data from 18 controlled trials involving over 2000 patients to assess if vitamin C affects the length of stay in the intensive care unit (ICU). The results suggest that vitamin C supplementat…
Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response
This narrative review examines how fragments of hyaluronan (HA), a major component of the extracellular matrix, contribute to inflammation. During tissue injury, large HA molecules are broken down into smaller pieces. E…
Fascial organisation of motor synergies: a hypothesis
This hypothesis paper explores how fascia helps organize movement through what are known as motor synergies. It suggests that instead of the brain controlling every muscle individually, the fascial system acts as a phys…
Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body
Interstitial fluid, the fluid in the spaces between our cells, has long been thought to move only over short distances. This study proposes a different view, suggesting that a network of fibrous connective tissues acts…