Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2019
Genetics of lipedema: new perspectives on genetic research and molecular diagnoses
S Paolacci, V Precone, F Acquaviva, P Chiurazzi, E Fulcheri, M Pinelli, F Buffelli, S Michelini, K L Herbst, V Unfer, M…This 2019 review explored the genetic basis of lipedema. The researchers summarized existing knowledge to highlight the need for a genetic test to aid in diagnosis. They identified several genetic factors that may be re…
lipedemalipoedemaDifferential diagnosisSubcutaneous fatGenetic diagnosis - B2019
Modeling and simulation of musculoskeletal system of human lower limb based on tensegrity structure
Zhanxi Wang, Chaoran Yang, Kang Feng, Xiansheng QinResearchers created a computer model of the human lower limb's musculoskeletal system using tensegrity principles, which balance tension and compression. Using an established muscle model (the Hill model), they simulate…
Tensegrity structure; lower limb model; motion analysis; gait simulation - B2019
Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response
Angela Avenoso, Giuseppe Bruschetta, Angela D'Ascola, Michele Scuruchi, Giuseppe Mandraffino, Rosa Gullace, Antonino Sa…This narrative review examines how fragments of hyaluronan (HA), a major component of the extracellular matrix, contribute to inflammation. During tissue injury, large HA molecules are broken down into smaller pieces. E…
Hyaluronan fragments NF-kB TLR-4 Cytokines Tissue damage Inflammation Hyaluronan degradation - A2019
Anatomy, Fascia
Bruno Bordoni, Navid Mahabadi, Matthew VaracalloThis resource provides an overview of the anatomy of fascia. As the full text has not yet been reviewed, this summary is based on the title alone. The entry likely covers the structural and functional aspects of fascial…
fascia - A++2019
Ketogenic Diet and Microbiota: Friends or Enemies
Antonio Paoli, Laura Mancin, Antonino Bianco, Ewan Thomas, João Felipe Mota, Fabio PicciniThis narrative review explores the relationship between the very low-carbohydrate ketogenic diet (VLCKD) and the gut microbiota. The community of microbes in our gut is a dynamic entity known to play a fundamental role…
gut microbiota; gut microbiome; intestinal microbiome; ketogenic diet; ketogenic diet and fat - A2019
Experimental myofascial trigger point creation in rodents
Ramon Margalef, Marc Sisquella, Marc Bosque, Clara Romeu, Orlando Mayoral, Sonia Monterde, Mercedes Priego, Rafael Guer…This animal study investigated how myofascial trigger points might form. Researchers treated mice and rats with a substance that increases nerve signals to the muscles, mimicking a state of high neurotransmission. This…
animal model; endplate noise; myofascial pain syndrome; myofascial trigger point; spontaneous acetylcholine release - A2019
Myofascial Chains of the Upper Limb: A Systematic Review of Anatomical Studies
JAN WILKE, FRIEDER KRAUSEThis systematic review compiled research to determine if myofascial chains, previously identified in the trunk and lower limbs, also exist in the upper limb. Analyzing 13 anatomical dissection studies, the authors found…
continuity; fascia; force transmission; muscles; cadavers; connective tissue; myofascial chains - B2019
Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology
Saba Nayar, Joana Campos, Charlotte G Smith, Valentina Iannizzotto, David H Gardner, Frédéric Mourcin, David Roulois, J…In sites of chronic inflammation or infection, connective tissue cells called fibroblasts can change their behavior. This study shows how a specific group of fibroblasts transforms into a network of so-called "immunofib…
FibroblastsSjögren’s syndromeautoimmunitytertiary lymphoid structures - 1A+2019
Fascia Is Able to Actively Contract and May Thereby Influence Musculoskeletal Dynamics: A Histochemical and Mechanographic Investigation
Robert Schleip, G Gabbiani, Jan Wilke, I Naylor, B Hinz, A Zorn, Heike Jäger, R Breul, S Schreiner, Werner KlinglerThis study investigated whether fascia can actively contract, challenging the traditional view of it as a passive tissue. Researchers examined human and rat fascial samples for the presence of contractile cells called m…
Connective tissuestiffnessmyofibroblastscontractilitycontracture - A2019
Distinct fibroblast subsets drive inflammation and damage in arthritis
Adam P Croft, Joana Campos, Kathrin Jansen, Jason D Turner, Jennifer Marshall, Moustafa Attar, Loriane Savary, Corinna…This study in mice investigated the role of fibroblasts, a type of connective tissue cell, in arthritis. Researchers identified two distinct subsets of fibroblasts with different functions. One type, located in the syno…
Synovial fibroblasts; inflammation; arthritis; transcriptomics; rheumatoid arthritis - A+2019
Overuse Injury: The Result of Pathologically Altered Myofascial Force Transmission?
Jan Wilke, Andry Vleeming, Scott WearingIn this narrative review, the authors propose a new perspective on overuse injuries. Traditionally, therapy focuses on the site of pain, viewing the injury as the result of local, repetitive microdamage. The authors hyp…
Myofascial force transmissionoveruse injuryfascitismusculoskeletal disorder - A++2019
Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
Liping Gan, Vladimir Camarena, Sushmita Mustafi, Gaofeng WangIn this study using cell cultures and animal models, researchers investigated how vitamin C might inhibit the spread of triple-negative breast cancer (TNBC). They found that vitamin C, at concentrations achievable throu…
F-actin; HIF-1α; YAP1; hippo pathway; lamellipodia; metastasis; synaptopodin 2; triple-negative breast cancer; vitamin C.