Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- B2019
The secret life of proteins
Abigail SawyerThe traditional scientific view has long held that single protein molecules are electrical insulators. However, a recent discovery overturns this belief, suggesting instead that proteins are strong electrical conductors…
AntibodyAntigenConductorElectrica L SignalsProtein - A2019
Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer
Anastasia G Tavianatou, Ilaria Caon, Marco Franchi, Zoi Piperigkou, Devis Galesso, Nikos K KaramanosThis narrative review explores how hyaluronan (HA), a key component of the extracellular matrix, functions differently depending on its molecular size. Large, high-molecular weight HA has different biological properties…
cancer; CD44; cell signaling; hyaluronan; inflammation; pharmacological targeting; RHAMM - A2019
Educational Avenues for Promoting Dialog on Fascia
Rebecca L PrattThis article argues that fascia is a critically important, yet often overlooked, organ system in healthcare education. The author highlights fascia's diverse roles in pathology, fluid movement, proprioception, pain perc…
fascia; connective; tissue; curriculum; anatomy - A2019
Oral Collagen Supplementation: A Systematic Review of Dermatological Applications
Franchesca D Choi, Calvin T Sung, Margit L W Juhasz, Natasha Atanaskova MesinkovskThis systematic review examined eleven clinical trials investigating the impact of oral collagen supplements on skin health. The findings suggest that collagen hydrolysates and peptides may improve skin elasticity, hydr…
wound healingcollagenskin aging - A+++2019
Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials
Juan Mario García-Coronado, Lorena Martínez-Olvera, Rodrigo E Elizondo-Omaña, Carlos Alberto Acosta-Olivo, Félix Vilche…This meta-analysis of five randomized placebo-controlled trials evaluated the impact of oral collagen supplementation on osteoarthritis (OA) symptoms. The findings suggest that collagen may help reduce the overall disea…
Collagen supplementation; Meta-analysis; Osteoarthritis symptoms; Visual Analogue Scale; WOMAC index - A2019
Distinct fibroblast subsets drive inflammation and damage in arthritis
Adam P Croft, Joana Campos, Kathrin Jansen, Jason D Turner, Jennifer Marshall, Moustafa Attar, Loriane Savary, Corinna…This study in mice investigated the role of fibroblasts, a type of connective tissue cell, in arthritis. Researchers identified two distinct subsets of fibroblasts with different functions. One type, located in the syno…
Synovial fibroblasts; inflammation; arthritis; transcriptomics; rheumatoid arthritis - A++2019
Induced lumbosacral radicular symptom referral patterns: a descriptive study
Michael B Furman, Stephen C JohnsonThis observational study investigated actual pain patterns caused by irritating specific nerve roots in the lower back. Clinicians often use standard 'dermatome' maps to diagnose the source of radiating leg pain, but pa…
dermatomes; nerve; communications; map; cutaneous; sensory - A2019
Ultrasound Imaging of the Fascial Layers
Carmelo Pirri, Carla Stecco, Levent ÖzçakarThis publication, for which a full summary is not yet available, appears to discuss using ultrasound to visualize the body's fascial layers. Ultrasound imaging is a non-invasive technique that provides real-time views o…
ultrasound.fascial layers - B2019
Modeling and simulation of musculoskeletal system of human lower limb based on tensegrity structure
Zhanxi Wang, Chaoran Yang, Kang Feng, Xiansheng QinResearchers created a computer model of the human lower limb's musculoskeletal system using tensegrity principles, which balance tension and compression. Using an established muscle model (the Hill model), they simulate…
Tensegrity structure; lower limb model; motion analysis; gait simulation - C2019
Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models
Anne-Laure Papa, Amanda Jiang, Netanel Korin, Michelle B Chen, Erin T Langan, Anna Waterhouse, Emma Nash, Jildaz Carof,…Platelets are crucial for blood clotting but can also contribute to thrombosis and cancer metastasis. In this preclinical study, researchers created modified human platelets, called "platelet decoys," that retained thei…
Plateletplatelet decoystrombosismetastatic tumors - A+++2019
Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials
Mikee Liugan, Anitra C CarrThis systematic review examined how vitamin C supplementation affects neutrophils, a key type of immune cell. Researchers analyzed 16 randomized controlled trials that measured neutrophil functions like their ability to…
vitamin C; ascorbic acid; neutrophils; polymorphonuclear leukocytes; migration; chemotaxis; apoptosis; phagocytosis; oxidative burst; systematic review - A2019
Innervation of the thoracolumbar fascia
Siegfried MenseThis study, conducted primarily on rats, investigated the types of nerves in the thoracolumbar fascia (TLF) to better understand its sensory roles. Researchers found only free nerve endings, many of which are associated…
NociceptionThoracolumbar fasciainnervationfree nerve endingsproprioception