Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesEffects of season long participation on ACL volume in female intercollegiate soccer athletes
This study investigated how a competitive season affects the anterior cruciate ligament (ACL) in female collegiate soccer players. Researchers used MRI scans to measure ACL volume in 17 athletes before and after their s…
The Other Side of the Fascia: The SmoothMuscle Part 1
This theoretical article challenges the standard definition of fascia. Traditionally, fascia is considered connective tissue originating from two embryonic layers, the mesoderm and ectoderm. The authors propose expandin…
The Fascial Connections of the Pectineal Ligament
This anatomical study investigated the detailed fascial connections of the pectineal ligament using dissection and analysis of ten human specimens. Researchers found the ligament acts as a connective tissue junction bet…
Role of a natural integrator based on lipoic acid, palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometriosis
This study investigated a nutritional supplement for endometriosis-related pain. Sixty women with ovarian endometriosis and chronic pelvic pain took a supplement containing alpha-lipoic acid, palmitoylethanolamide (PEA)…
Vitamin C administration in the critically ill: a summary of recent meta-analyses
This 2019 publication is a summary of recent meta-analyses on the topic of vitamin C administration for critically ill patients. As the full text has not yet been reviewed, a detailed summary of its findings is not avai…
Evaluation of hyaluronan content in areas of densification compared to adjacent areas of fascia
This entry is currently a title only, so a full summary is not available. Based on the title, the researchers appear to have evaluated and compared the hyaluronan content in areas of fascial densification with the conte…
High Cortisol and the Risk of Dementia and Alzheimer's Disease: A Review of the Literature
This literature review examines the relationship between the stress hormone cortisol and the risk of dementia and Alzheimer’s disease. The research suggests that chronically elevated cortisol levels may have deleterious…
Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes
This animal study investigated myodural bridges—connective tissue links between small neck muscles and the spinal cord's outer covering (dura mater)—in horses. Researchers compared horses with a genetic connective tissu…
High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
This study on breast cancer cells in the lab and in mice explored how different doses of vitamin C affect cancer cell behavior. Researchers found that low and medium doses of vitamin C seemed to encourage cancer cells t…
Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer
This narrative review explores how hyaluronan (HA), a key component of the extracellular matrix, functions differently depending on its molecular size. Large, high-molecular weight HA has different biological properties…
Extracellular matrix composition of connective tissues: a systematic review and meta-analysis
This systematic review and meta-analysis compiled data to quantify the protein composition of the extracellular matrix (ECM) in various human connective tissues. Researchers analyzed data from studies on bone, adipose t…
Lipedema: friend and foe
Lipedema is a chronic disorder characterized by painful, disproportionate fat accumulation in the limbs of women, and is often misdiagnosed as obesity. In this review, researchers examined both the negative ('foe') and…