Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2019
Genetics of lipedema: new perspectives on genetic research and molecular diagnoses
S Paolacci, V Precone, F Acquaviva, P Chiurazzi, E Fulcheri, M Pinelli, F Buffelli, S Michelini, K L Herbst, V Unfer, M…This 2019 review explored the genetic basis of lipedema. The researchers summarized existing knowledge to highlight the need for a genetic test to aid in diagnosis. They identified several genetic factors that may be re…
lipedemalipoedemaDifferential diagnosisSubcutaneous fatGenetic diagnosis - A+++2019
Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury
Enrico Sangiovanni, Marco Fumagalli, Barbara Pacchetti, Stefano Piazza, Andrea Magnavacca, Saba Khalilpour, Gloria Melz…This in vitro study investigated how Cannabis sativa extract and its component cannabidiol (CBD) affect inflammation in human skin cells. Researchers found that both the extract and pure CBD reduced the release of sever…
Cannabis sativa L.; cannabidiol; fibroblasts; keratinocytes; skin inflammation; wound injury. - A+++2019
Is It All About the Fascia? A Systematic Review and Meta-analysis of the Prevalence of Extramuscular Connective Tissue Lesions in Muscle Strain Injury
Jan Wilke, Luiz Hespanhol, Martin BehrensThis systematic review and meta-analysis examined how often connective tissue is damaged in athletic muscle strains. Researchers analyzed 16 imaging studies and found that lesions to the fascia and tendons are highly pr…
return to play; muscle injury; collagen; imaging; ultrasound; MRI - 1A+2019
The Awareness of the Fascial System
Bruno Bordoni, Marta SimonelliIn this theoretical article, the authors propose a new way of looking at the fascial system, drawing on concepts from quantum physics. They suggest that fascial cells can sense, remember, and even anticipate mechanical…
fasciafascial systemMyofascialquantum physicsphysiology - A+++2019
Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts
Thivanka Muthumalage, Irfan RahmanThis laboratory study investigated how cannabidiol (CBD) influences inflammatory responses in lung epithelial cells, fibroblasts, and immune cells. The researchers found that CBD can reduce inflammation triggered by ext…
CBD; E-cigarette; E-liquid; Lung; Marijuana; Vaping - A+++2019
Vitamin C administration in the critically ill: a summary of recent meta-analyses
Anitra C CarrThis 2019 publication is a summary of recent meta-analyses on the topic of vitamin C administration for critically ill patients. As the full text has not yet been reviewed, a detailed summary of its findings is not avai…
Vitamin CAscorbic acidsepsis - A2019
Lipedema: A Call to Action!
Giacomo Buso, Michele Depairon, Didier Tomson, Wassim Raffoul, Roberto Vettor, Lucia MazzolaiThis narrative review summarizes the current understanding of lipedema, a chronic and progressive disease primarily affecting women. It is characterized by a painful, abnormal distribution of fat in the limbs, which oft…
lymphedemalipedema; obesity - A2019
Lymphatic pump manipulation in patients with chronic obstructive pulmonary disease
Bruno BordoniThis narrative review examines the use of lymphatic pump manipulation for patients with chronic obstructive pulmonary disease (COPD). COPD is characterized by persistent inflammation, and lymphatic techniques aim to red…
inflammationfasciaOsteopathicCOPDlymphatic pump - A2019
Cranial osteopathy: Obscurantism and Enlightenment
Bruno Bordoni, Bruno Morabito, Marta SimonelliIn this reflective article, the authors discuss the controversial aspects of cranial osteopathy. They address common objections, such as the idea that the cranial bones are immobile in adults and that an operator's hand…
fasciaOsteopathicquantum physicsneurophysiologycranio - 1A+2019
The Other Side of the Fascia: The SmoothMuscle Part 1
Bruno Bordoni, Marta Simonelli, Bruno MorabitoThis theoretical article challenges the standard definition of fascia. Traditionally, fascia is considered connective tissue originating from two embryonic layers, the mesoderm and ectoderm. The authors propose expandin…
fasciaMyofascialOsteopathicsmooth musclemesoderm - A+2019
Anti-Inflammatory Diets and Fatigue
Ulrike Hass, Catrin Herpich, Kristina NormanThis narrative review explores the link between pro-inflammatory status and chronic disease-related fatigue in conditions such as cancer, fibromyalgia, and chronic fatigue syndrome. While evidence for individual nutrien…
anti-inflammatory nutrition; cancer; chronic fatigue; cytokines; fatigue reduction diet; inflammation; myalgic encephalomyelitis; omega-3 fatty acids; polyphenols; probiotics. - A++2019
Local Vibration Stimuli Induce Mechanical Stress-Induced Factors and Facilitate Recovery From Immobilization-Induced Oxidative Myofiber Atrophy in Rats
Fusako Usuki, Masatake Fujimura, Atsushi Nakamura, Jiro Nakano, Minoru Okita, Itsuro HiguchiThis study on rats investigated whether local vibration could help muscles recover after being immobilized. Researchers put a cast on one hindlimb of the rats for a week to induce muscle atrophy. After removing the cast…
YAP1; local vibration; mechano-growth factor; mechanotransduction; oxidative myofiber atrophy; satellite cell; therapeutics.