Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesProtein—glycosaminoglycan interaction networks: Focus on heparan sulfate
This research overview describes a project focused on glycosaminoglycans (GAGs), complex sugars found on the cell surface and in the extracellular matrix. Specifically, it investigates heparan sulfate and how it interac…
Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation
Platelets play a key role in responding to tissue injury. This study explores how they interact with hyaluronan, a major component of the extracellular matrix that is involved in inflammation. Researchers demonstrated t…
The extracellular matrix: Tools and insights for the “omics” era
This narrative review discusses the extracellular matrix (ECM), the complex network of proteins and molecules that provides structural and chemical support to our cells and tissues. Alterations in the ECM are associated…
Remodelling the extracellular matrix in development and disease
This narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…
Modes of cancer cell invasion and the role of the microenvironment
For cancer to spread, or metastasize, tumor cells must first invade the surrounding connective tissue (stroma). This review article describes how cancer cells can move in different ways—either as single cells or in coll…
Hyaluronan: Biosynthesis and signaling
This 2014 narrative review discusses hyaluronan (HA), a key component of the extracellular matrix. Beyond its structural role in tissue hydration and architecture, HA is an active signaling molecule. The authors highlig…
Biotensegrity of the extracellular matrix: physiology, dynamic mechanical balance, and implications in oncology and mechanotherapy
This 2014 review article explores the concept of biotensegrity, a principle where cells and tissues maintain structural integrity through a balance of tension and compression. This dynamic mechanical balance involves th…
Mechanotransduction and extracellular matrix homeostasis
Connective tissues are dynamic, constantly adapting even at rest. Cells within these tissues continually sense mechanical cues from their environment through a process called mechanotransduction. In response, they maint…
A decorin-deficient matrix affects skin chondroitin/dermatan sulfate levels and keratinocyte function
This study in mice investigated how the absence of a proteoglycan called decorin affects skin structure and function. Researchers found that mice lacking decorin had an altered composition of other sugar molecules (chon…
Fascia Research Congress Evidence from the 100 year perspective of Andrew Taylor Still
This review paper examines research from the first three International Fascia Research Congresses through the perspective of Andrew Taylor Still, the founder of osteopathic medicine. Over a century ago, Still described…
Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective
This review article examines the extracellular matrix (ECM), the dynamic network of molecules surrounding our cells. The authors focus on fibrous proteins like collagen and elastin, which form the structural backbone of…
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis
Fibrosis is a process of excessive connective tissue formation, leading to scarring and stiffness in organs. A protein called Connective Tissue Growth Factor (CTGF) plays a central role in driving this process. This res…