Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2013
Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection
Yejin Kim, Hyemin Kim, Seyeon Bae, Jiwon Choi, Sun Young Lim, Naeun Lee, Joo Myung Kong, Young-il Hwang, Jae Seung Kang…This animal study investigated how vitamin C affects the immune response to influenza A virus (H3N2). Researchers used mice that, like humans, cannot synthesize their own vitamin C. When these mice were made vitamin C-d…
immune responseVitamin Cantiviralinfluenza Ainterferon alfa/beta - A+2013
Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
Leung-Kim Hung, Sai-Chuen Fu, Yuk-Wa Lee, Tsui-Yu Mok, Kai-Ming ChanThis animal study investigated whether vitamin C could reduce scar tissue formation after a tendon injury. Researchers injured a flexor tendon in chickens and then injected either vitamin C or a saline solution at the s…
Vitamin Chealing tendonadhesion - B2013
Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes
ANTONIO CERIELLO, ANNA NOVIALS, EMILIO ORTEGA, SILVIA CANIVELL, LUCIA LA SALA, GEMMA PUJADAS, LOREDANA BUCCIARELLI, MAU…Acute low blood sugar (hypoglycemia) in people with type 1 diabetes can cause oxidative stress, inflammation, and damage to the lining of blood vessels. This study investigated whether the hormone GLP-1 and vitamin C co…
Oxidative stressdiabetesVitamin C - A++2013
Vitamin C in Disease Prevention and Cure: An Overview
Shailja Chambial, Shailendra Dwivedi, Kamla Kant Shukla, Placheril J John, Praveen SharmaThis narrative review provides an overview of Vitamin C's many roles in the body. It is essential for developing and maintaining connective tissues, and plays a key part in bone formation, wound healing, and gum health.…
cancerdiabetesVitamin CImmunityinfertility - A2013
Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
Anitra C Carr, Stephanie M Bozonet, Juliet M Pullar, Jeremy W Simcock, Margreet C M VissersThis study investigated how vitamin C intake affects its concentration in human skeletal muscle. Researchers gave 36 men either half a kiwifruit or two kiwifruits daily for six weeks, as kiwifruit is a rich source of vi…
Vitamin Cascorbate - A2011
The Genetics of Vitamin C Loss in Vertebrates
Guy Drouin, Jean-Rémi Godin, Benoît PagéThis narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…
BiosynthesisVitamin CAscorbic acidGLO geneL-gulono-gamma-lactone oxidase - A2008
Anti-angiogenic effect of high doses of ascorbic acid
Nina A Mikirova, Thomas E Ichim, Neil H RiordanThis laboratory study investigated how high doses of ascorbic acid (vitamin C) affect the formation of new blood vessels, a process called angiogenesis. Researchers exposed several types of human endothelial cells, incl…
AngiogenesisVitamin CAscorbic acid - A2007
Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
Yoo-Sin Park, Si-Woong Lim, Il-Hoon Lee, Tae-Jin Lee, Jong-Sung Kim, Jin Soo HanIn this animal study, researchers investigated if injecting a simple nutrient solution could protect knee cartilage in rabbits with induced osteoarthritis. The solution, containing glucose, amino acids, and vitamin C, w…
nutritionosteoarthritisVitamin Cascorbateintra articular - A+2005
Nutraceutical Therapies for Degenerative Joint Diseases: A Critical Review
ROBERT GOGGS, ANNE VAUGHAN-THOMAS, PETER D CLEGG, STUART D CARTER, JOHN F INNES, ALI MOBASHERI, MEHDI SHAKIBAEI, WOLFGA…This 2005 critical review examines the role of nutrition in managing degenerative joint diseases like osteoarthritis. The authors suggest that while nutritional factors are crucial for cartilage health, dietary programs…
articular cartilagenutritionosteoarthritisnutraceuticalVitamin C - A2003
Vitamin C, respiratory infections and the immune system
Harri HemiläThis 2003 publication by Harri Hemilä explores the relationship between Vitamin C, respiratory infections, and immune system function. As only the title is available, specific conclusions regarding the study's exact res…
Vitamin CAscorbic acid - A1994
Glutathione-Ascorbic Acid Antioxidant System in Animals
Alton MeisterThis 1994 publication by Alton Meister discusses the biochemical interaction between glutathione and ascorbic acid (Vitamin C) within animal antioxidant systems. As the source material is limited to the title, the summa…
Vitamin CAscorbic acidantioxidantanimals - A++1990
Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig
M Rath, L PaulingThis animal study investigated the link between vitamin C, a specific cholesterol particle called Lipoprotein(a) or Lp(a), and atherosclerosis. Researchers found that guinea pigs, which like humans cannot produce their…
Vitamin CAscorbic acidAtherosclerosis