Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials
Natiele Camponogara Righi, Felipe Barreto Schuch, Angélica Trevisan De Nardi, Caroline Montagner Pippi, Geovana de Alme…This meta-analysis compiled results from 18 randomized clinical trials to investigate the effects of vitamin C supplementation following a single bout of exercise. The researchers found that vitamin C reduced certain ma…
inflammationOxidative stressexerciseathleteAscorbic acid - A+++2020
Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation
Dennis Muñoz Vergara, Lisbeth Berrueta, Colleen Carmody, Xingxing An, Peter M Wayne, Ann Marie Zavacki, Helene M Langev…This animal study used a novel porcine model to investigate how active stretching affects controlled inflammation in the connective tissue of the back. Researchers trained pigs to perform a specific stretch twice daily…
Stretch - A+++2020
Mechanical stimulation of human dermal fibroblasts regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies
Aric Anloague, Aaron Mahoney, Oladipupo Ogunbekun, Taylor A Hiland, William R Thompson, Bryan Larsen, M Terry Loghmani,…This lab study investigated how mechanical forces, similar to those in manual therapy, affect human skin cells. Researchers first applied a repetitive strain to cultured dermal fibroblasts to simulate an overuse injury,…
inflammationMyofascial releaseManual Therapyphysical therapyphysiotherapy - A2020
Quantitative analysis of gliding between subcutaneous tissue and the vastus lateralis - Influence of the dense connective tissue of the myofascia
Kengo Kawanishi, Shintarou KudoThis study investigated the relationship between the thickness of connective tissue layers and their ability to glide past one another. Using ultrasound, researchers observed the vastus lateralis muscle on the outer thi…
Connective tissue; GLIDING; Particle image velocimetry. - A+2020
Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis 24-month randomized, double-blind, placebo-controlled crossover study investigated the effects of daily resveratrol supplementation in 125 postmenopausal women. The researchers found that regular intake of 75 mg re…
Resveratrolsupplementation - A++2020
The potential role of cannabinoids in dermatology
Tabrez Sheriff, Matthew J Lin, Danielle Dubin, Hooman KhorasaniThis literature review explores how cannabinoids, including both plant-derived and endogenous versions, may affect the skin through the endocannabinoid system. Research suggests that the skin possesses its own receptors…
Cannabinoids in dermatology; cannabidiol; cannabis; endocannabinoids. - A2020
A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes
Claire Shortt, Leonard G Luyt, Eva A Turley, Mary K Cowman, Thorsten KirschInflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…
hyaluronaninflammationchondrocytesP15-1IL-1beta - A2020
The link between vitamin D and COVID-19: distinguishing facts from fiction
P BergmanThis 2020 article, available only by title, appears to be a review or commentary on the relationship between vitamin D and COVID-19. The title, "The link between vitamin D and COVID-19: distinguishing facts from fiction…
COVID-19vitamin D - A++2020
Mesothelial Cells Covering the Surface of Primo Vascular System Tissue
Chae Jeong Lim, Yeo Sung Yoon, Pan Dong RyuIn this study on rats, researchers investigated the cells on the outer surface of the primo vascular system (PVS), a proposed circulatory network. Using various microscopy and staining techniques, they identified these…
HBME-1; hematoxylin and eosin staining (H&E); periductium; primo node; primo vessel; scanning electron microscopy (SEM) - A2020
Virtual reality in the rehabilitation process for individuals with cerebral palsy and Down syndrome: A systematic review
Jamile Benite Palma Lopes, Natalia de Almeida Carvalho Duarte, Roberta Delasta Lazzari, Claudia Santos OliveiraThis systematic review compiled research on virtual reality (VR) as a rehabilitation tool for children with cerebral palsy and Down syndrome. Researchers analyzed five high-quality studies and found that VR training, bo…
Cerebral palsy; Down syndrome; Movement analysis; Virtual reality. - A+++2020
Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
Eduardo Dourado, Margarida Ferro, Catarina Sousa Guerreiro, João Eurico FonsecaThis narrative review explores how dietary patterns can influence the gut microbiota in individuals with rheumatoid arthritis (RA). Research indicates that RA patients often exhibit significant differences in their inte…
Mediterranean diet; gut microbiota; probiotics; rheumatoid arthritis - C2020
Endothelial mechanobiology
Ming He, Marcy Martin, Traci Marin, Zhen Chen, Brendan GongolThis narrative review explores how the cells lining our blood vessels, called endothelial cells, respond to the mechanical forces of blood flow. It describes two main patterns: smooth, pulsatile flow in straight vessels…
mechanotransductionmechanpbiologyendothelial cellsvasculatory disease